Results 81 to 90 of about 286,506 (354)

Epimorphin regulates bile duct formation via effects on mitosis orientation in rat liver epithelial stem-like cells.

PLoS ONE, 2010
Understanding how hepatic precursor cells can generate differentiated bile ducts is crucial for studies on epithelial morphogenesis and for development of cell therapies for hepatobiliary diseases.
Junnian Zhou, Lei Zhao, Lipeng Qin, Jing Wang, Yali Jia, Hailei Yao, Chen Sang, Qinghua Hu, Shuangshuang Shi, Xue Nan, Wen Yue, Fengyuan Zhuang, Chun Yang, Yunfang Wang, Xuetao Pei   +14 more
doaj   +1 more source

Transplantation of patient‐specific bile duct bioengineered with chemically reprogrammed and microtopographically differentiated cells

Bioengineering & Translational Medicine, 2022
Cholangiopathy is a diverse spectrum of chronic progressive bile duct disorders with limited treatment options and dismal outcomes. Scaffold‐ and stem cell‐based tissue engineering technologies hold great promise for reconstructive surgery and tissue ...
Elina Maria Buisson, Suk‐Hee Park, Myounghoi Kim, Kyojin Kang, Sangtae Yoon, Ji Eun Lee, Young Won Kim, Nak Kyu Lee, Mi Ae Jeong, Bo‐Kyeong Kang, Seung Bum Lee, Valentina M. Factor, Daekwan Seo, Hyunsung Kim, Jaemin Jeong, Han Joon Kim, Dongho Choi   +16 more
doaj   +1 more source

Correlation of mechanical factors and gallbladder pain [PDF]

, 2008
Acalculous biliary pain occurs in patients with no gallstones, but is similar to that experienced by patients with gallstones. Surgical removal of the gallbladder (GB) in these patients is only successful in providing relief of symptoms to about half of ...
Bird, N.C., Chin, S.B., Hill, N.A., Johnson, A.G., Li, W.G., Luo, X.Y., Smythe, A.   +6 more
core   +3 more sources

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

The Silent Liver Function Mayhem: Unrevealing The Mystery Of Vanishing Bile Duct Syndrome

Pakistan Journal of Medicine and Dentistry
Vanishing Bile Duct Syndrome (VBDS) is a rare form of cholestatic liver disease that is characterized by the destruction of intrahepatic biliary tree segments.
Shafay Aamir, Muhammad Abdullah Rashid, Uzair Ahmed Khan, Rabia Arshad   +3 more
doaj   +1 more source

Re-do Kasai procedure in a preterm infant

Journal of Pediatric Surgery Case Reports, 2019
We report the case of a 10-day old boy with biliary atresia (BA) who was delivered by caesarean section at 33 weeks 4 days of gestation (birth weight, 2135 g). At birth, his direct bilirubin level was high, and stools were light yellow.
Hiromu Tanaka, Hideyuki Sasaki, Masatoshi Hashimoto, Masaki Nio   +3 more
doaj   +1 more source

Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia [PDF]

, 1976
In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there
Hansbrough, JF, Hoelscher, M, Porter, KA, Putnam, CW, Schröter, GPJ, Starzl, TE   +5 more
core   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source