Results 101 to 110 of about 15,104 (253)

Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records

Movement Disorders, EarlyView.
Abstract Background Ursodeoxycholic acid (UDCA) has shown mitochondrial and neuroprotective effects and has been proposed as a treatment for Parkinson's disease (PD). However, population‐level evidence on its effect on PD risk is lacking. Objectives To compare the risk of incident PD among UDCA initiators versus matched non‐initiators within a ...
Chengsheng Ju, Anette Schrag, Camille Carroll, Xi Xiong, James Carpenter, Oliver Bandmann, Thomas Foltynie, Li Wei   +7 more
wiley   +1 more source

EXPLORATION OF THE COMMON BILE DUCT

Annals of Surgery, 1940
openaire   +3 more sources

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Prandial Effects on Intravoxel Incoherent Motion Quantification in the Liver

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate the feasibility of detecting prandial (i.e., meal) induced changes in microvascular flow in the liver, including changes in the spatial distribution of flow velocities, using intravoxel incoherent motion (IVIM) MRI. Methods Thirteen (n = 13) healthy volunteers underwent two liver MR exams: one preprandial after fasting and ...
Gregory Simchick, A. M. K. Muntasir Shamim, Alexandra Anagnostopoulos, Kevin M. Johnson, Diego Hernando   +4 more
wiley   +1 more source

Intelligent Continuum Micromachines in Complex Confined Spaces

SmartBot, EarlyView.
The cover depicts a conceptual design for an intelligent continuum micromachine entering a target capsule used in fusion‐energy research through its slender gas‐fill tube. By combining route‐adaptive deformation, embedded sensing, and a functional end effector, the robot could inspect hidden defects, assess local conditions, and support localized ...
Huayang Sai, Yunyue Yang, Shuxing Xu, Jinbo Hu, Jiliang Wang, Zhehao Gan, Wei Tang, Tian‐Yun Huang   +7 more
wiley   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

Robotic Cholecystectomy and Common Bile Duct Exploration: Multidisciplinary Approach in a Complex Case of Choledocholithiasis. [PDF]

J Clin Med
De Palma C, Delvecchio A, Varvara M, D'Errico F, Decembrino F, Di Giovanni G, Inchingolo R, Memeo R, Tedeschi M.   +8 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Through the scope, through the years: declining trends in laparoscopic common bile duct exploration. [PDF]

Surg Endosc
Bloom MB, Gonsalves N, Chen Y, Tseng J, Mirshojae S, Rawal R, Amersi F, Phillips E.   +7 more
europepmc   +1 more source

Characterization of the Middle Ear Microbiome in Meniere's Disease by 16S rRNA Gene Sequencing Compared to Chronic Suppurative Otitis Media

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To investigate the middle ear microbiome in Meniere's disease (MD) patients. Methods Middle ear smears from 10 MD patients (ME group) and 10 chronic suppurative otitis patients (OE group) were collected during surgery and processed via 16S rRNA gene sequencing.
Yu‐Ting Tao, Lin Wang, Hong‐wei Zheng, Li‐Sheng Yu   +3 more
wiley   +1 more source