Results 11 to 20 of about 132,411 (308)

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury [PDF]

Digestive Surgery, 2019
Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation ...
Carpino, Guido, de Jong, Iris E M, Gaudio, Eugenio, Gouw, Annette S H, Iswandana, Raditya, Lisman, Ton, Matton, Alix P M, Olinga, Peter, Oosterhuis, Dorenda, Overi, Diletta, Porte, Robert J, Suriguga, Su, van Haaften, Wouter T, van Praagh, Jasper B, van Wijk, Louise A, Wiersema-Buist, Janneke   +15 more
core   +8 more sources

PAUCITY OF INTRAHEPATIC BILE DUCTS

Вестник трансплантологии и искусственных органов, 2013
The paucity of intrahepatic bile ducts is characterized by reducing the quantity of interlobular bile ducts in re- lation to portal tracts of the liver.
O. E. Iryshkin, I. M. Iljinsky, O. M. Tsirulnikova   +2 more
doaj   +2 more sources

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

Science, 2021
Organoids regenerate human bile ducts Bile ducts carry bile from the liver and gall bladder to the small intestine, where it aids digestion. Cholangiocytes are epithelial cells that line bile ducts and modify bile as its transported through the biliary ...
F. Sampaziotis, D. Muraro, Olivia C. Tysoe, S. Sawiak, T. Beach, E. Godfrey, S. Upponi, T. Brevini, B. Wesley, J. Garcia-Bernardo, Krishnaa T. A. Mahbubani, Giovanni Canu, Richard L. Gieseck, N. L. Berntsen, Victoria L. Mulcahy, K. Crick, C. Fear, Sharayne Robinson, L. Swift, L. Gambardella, Johannes Bargehr, Daniel Ortmann, S. Brown, Anna Osnato, M. Murphy, G. Corbett, W. Gelson, G. Mells, Peter Humphreys, S. Davies, I. Amin, P. Gibbs, S. Sinha, S. Teichmann, A. Butler, T. See, E. Melum, C. Watson, K. Saeb‐Parsy, L. Vallier   +39 more
semanticscholar   +1 more source

Large duct intrahepatic cholangiocarcinoma arising from intraductal papillary neoplasm of bile duct: A rare case report

Medical Science, 2023
Intrahepatic cholangiocarcinoma (iCCA) is one of the primary carcinomas of the bile duct. It is a malignant intrahepatic epithelial neoplasm with biliary differentiation arising in the liver periphery/proximal to the left and right hepatic ducts with ...
N. A, T. J., Rajendran, S. B
semanticscholar   +1 more source

Early intrahepatic duct defects in a cystic fibrosis porcine model

Physiological Reports, 2021
Hepatobiliary disease causes significant morbidity and mortality in people with cystic fibrosis (CF), yet this problem remains understudied. Previous studies in the newborn CF pig demonstrated decreased bile flow into the small intestine and a ...
Keyan Zarei, David K. Meyerholz, David A. Stoltz   +2 more
doaj   +1 more source

Surgical Treatment of Intraductal Papillary Neoplasm of the Bile Duct: A Report of Two Cases and Review of the Literature

Frontiers in Oncology, 2022
Intraductal papillary neoplasm of the bile duct (IPNB) is a rare bile duct tumor characterized by intraductal papillary or villous neoplasms covered by neoplastic epithelium with fine fibrovascular stalks in the dilated bile ducts (1).
Binjie Li, Zhiqiang Liu, Zhuo Meng, Mingyang Li, Weijun Tian, Quanyan Liu   +5 more
doaj   +1 more source

Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro

Clinical and Translational Medicine, 2021
The well‐established 3D organoid culture method enabled efficient expansion of cholangiocyte‐like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies.
Floris J. M. Roos, Haoyu Wu, Jorke Willemse, R. Lieshout, Laura A Muñoz Albarinos, Yik Y. Kan, J. Poley, M. Bruno, J. de Jonge, R. Bártfai, H. Marks, J. Ijzermans, M. Verstegen, Luc J. W. van der Laan   +13 more
semanticscholar   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Intrahepatic Transposition of Bile Ducts [PDF]

ISRN Surgery, 2012
Objective. To describe the intrahepatic bile duct transposition (anatomical variation occurring in intrahepatic ducts) and to determine the frequency of this variation.Material and Methods. The researches were performed randomly on 100 livers of adults, both sexes. Main research methods were anatomical macrodissection.
Jasmin Delić, Admedina Savković, Eldar Isaković, Sergije Marković, Alma Bajtarevic, Amir Denjalić   +5 more
openaire   +2 more sources