Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]
arXiv, 2023 Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv
Approximate One-Dimensional Models for Monoenergetic Neutral Particle Transport in Ducts with Wall Migration [PDF]
Journal of Computational and Theoretical Transport 46.4 (2017):
242-257, 2016 The problem of monoenergetic neutral particle transport in a duct, where particles travel inside the duct walls, is treated using an approximate one-dimensional model. The one-dimensional model uses three-basis functions, as part of a previously derived weighted-residual procedure, to account for the geometry of particle transport in a duct system ...
arxiv +1 more source
Downregulation of intestinal Farnesoid X Receptor in Erythropoietic protoporphyria [PDF]
, 2017 Erythropoietic protoporphyria (EPP) is characterized by accumulation of protoporphyrin IX (PPIX) in the body. The liver is the major organ responsible for PPIX excretion through the biliary system. Because PPIX is highly hydrophobic, an excess amount of
Pradhan, Komal
core
Contribution of resident stem cells to liver and biliary tree regeneration in human diseases [PDF]
, 2018 Two distinct stem/progenitor cell populations of biliary origin have been identified in the adult liver and biliary tree. Hepatic Stem/progenitor Cells (HpSCs) are bipotent progenitor cells located within the canals of Hering and can be differentiated ...
Alvaro, Domenico +7 more
core +1 more source
REMEDI: REinforcement learning-driven adaptive MEtabolism modeling of primary sclerosing cholangitis DIsease progression [PDF]
arXiv, 2023 Primary sclerosing cholangitis (PSC) is a rare disease wherein altered bile acid metabolism contributes to sustained liver injury. This paper introduces REMEDI, a framework that captures bile acid dynamics and the body's adaptive response during PSC progression that can assist in exploring treatments.
arxiv
Highlight report: New insights in liver physiology [PDF]
, 2020 One of the central functions of the liver is excretion of bile into the intestine. Currently, bile excretion is explained by the osmotic model, according to which bile acids are excreted by hepatocytes into the bile canaliculi and since bile acids are ...
Ezzat Ahmed, Ahmed
core
Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury [PDF]
arXiv, 2023 During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the liver. Our recent study has shown a correlation between the bile-to-plasma ratio of FDA-approved sodium fluorescein (SF)
arxiv
"HISTOPATHOLOGY OF LIVER IN CATTLE SPONTANEOUSLY INFECTED WITH FASCIOLA HEPATICA AND FASCLOLA GLGANTICA IN IRAN" [PDF]
Iranian Journal of Public Health, 1982 A total of 1500 infected liver with F. hepatica and F. gigantica from slaughtered cattle in different parts of Iran were studied. Grossly the livers were usually irregular in shape, with prominent bile ducts on the visceral surface as grayish-white, firm-
J.Massoud, L.Vedadi
doaj +2 more sources
The use of modern techniques of biliary tract monitoring in percutaneous drainage [PDF]
, 2004 The aim of this work is to assess the usefulness of current imaging techniques of biliary tracts in percutaneous transhepatic biliary drainage (PTBD). In the period from January 1996 to March 2003 44 cases of PTBD were carried out under ultrasonographic ...
Ciesielczyk, B, Nowik, M
core +1 more source
Patterns of Pathomorphological Changes in Acute Necrotizing Pancreatitis
International Journal of Inflammation, 2012 Acinar necrosis is the basic microscopic sign of acute necrotizing pancreatitis (ANP). Microcirculation disorder is one of the major factors in the pathogenesis and morphogenesis of ANP besides free radicals and damage of enzymatic origin.
I. Kovalska +4 more
doaj +1 more source