Results 111 to 120 of about 1,208 (169)

What the European Reference Network Registry for Rare Liver Diseases Tells Us About Primary Biliary Cholangitis in European Practice

United European Gastroenterology Journal, EarlyView.
Marten A. Lantinga
wiley   +1 more source

Acute hepatitis and haemolysis associated with doxycycline and rifampin administration in two weanling foals

Equine Veterinary Education, EarlyView.
Summary Two foals were being treated with a combination of oral doxycycline and rifampin for presumed Rhodococcus equi infections. After 3–4 weeks of antimicrobial administration, both foals presented with icterus and nonspecific clinical signs, including lethargy and inappetence.
A. Murdock, D. Wong, T. Hall, B. Sponseller, J. Howard, K. Frerichs, A. Bianco, R. Ruby   +7 more
wiley   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Post‐Hemodialysis Flow‐Dependent Hepatic Function Impairment in Individuals With End Stage Kidney Disease and Chronic Inflammation

Hemodialysis International, EarlyView.
ABSTRACT Introduction The liver plays an important role to prevent translocation of gut‐derived toxins from the portal to the systemic circulation. Chronic inflammation is common in patients receiving hemodialysis, and increased gut permeability to microbial material has been implicated in its pathogenesis.
Oscar Swift, Bobby V. M. Dasari, Malcolm A. Finkelman, Yonglong Zhang, Sivakumar Sridharan, Enric Vilar, Ken Farrington   +6 more
wiley   +1 more source

Clinical Characteristics and Long‐Term Prognosis of Primary Biliary Cholangitis in Japan: Results of the 2nd‐Generation Nationwide Survey

Hepatology Research, EarlyView.
We have established the 2nd‐generation nationwide survey of PBC in Japan. Our analyses of the survey result not only highlight the demographical trend in Japanese PBC patients over time; they also validate the previously described risk factors for the patients' prognoses.
Yuki Kugiyama, Masanori Abe, Tadashi Namisaki, Hitoshi Yoshiji, Kazumichi Abe, Hiromasa Ohira, Ryosaku Shirahashi, Keiji Yokoyama, Atsushi Fukunaga, Kazuhito Kawata, Masahiro Umemura, Akira Honda, Tadashi Ikegami, Shiho Miyase, Toshiaki Nakano, Atsumasa Komori, Atsushi Tanaka, on behalf of the Japan PBC Study Group   +17 more
wiley   +1 more source

Altered Serum Bile Acid Pattern as an Independent Factor for Covert and Overt Hepatic Encephalopathy in Patients With Cirrhosis

Hepatology Research, EarlyView.
ABSTRACT Aim Bile acid (BA) signaling plays an important role in the pathogenesis of hepatic encephalopathy (HE), including covert (CHE) and overt HE (OHE). However, few studies have examined its clinical impact in patients with cirrhosis. Methods This retrospective study included patients with cirrhosis who underwent CHE assessment using a computer ...
Takao Miwa, Hajime Ueda, Teruo Miyazaki, Akira Honda, Tadashi Ikegami, Shinji Unome, Tatsunori Hanai, Yohei Shirakami, Masahito Shimizu   +8 more
wiley   +1 more source

Identification and Characterization of Three Novel Biomarkers for Mixed/Cholestatic Drug‐Induced Liver Injury

Hepatology Research, EarlyView.
Three metabolites, pyroglutamylglycine (pyroGluGly), phenylalanine (Phe), and phenylalanyltryptophan (PheTrp), were identified as candidate DILI biomarkers. The serum concentrations of pyroGluGly, Phe, and PheTrp demonstrated a high differentiating ability in patients with mixed and cholestatic DILI compared with those in patients who recovered from ...
Kosuke Saito, Tatehiro Kagawa, Keiji Tsuji, Yuji Kumagai, Ken Sato, Shotaro Sakisaka, Naoya Sakamoto, Mitsuhiko Aiso, Shunji Hirose, Nami Mori, Toshio Uraoka, Kazuhide Takata, Koji Ogawa, Kazuhiko Mori, Motonobu Sato, Takayoshi Nishiya, Kazuhiko Takamatsu, Noriaki Arakawa, Takashi Izumi, Ruri Kikura‐Hanajiri, Yasuo Ohno, Yoshiro Saito, Hajime Takikawa   +22 more
wiley   +1 more source

Effect of General Anesthesia on Liver and Spleen Stiffness for Predicting High‐Risk Varices in Biliary Atresia

Hepatology Research, EarlyView.
In children with biliary atresia (BA), breath‐holding during liver and spleen stiffness (LS and SS) measurement is often difficult, raising concerns about measurement reliability in the awake state. We investigated whether performing LS and SS measurements under general anesthesia—when brief ventilation pauses are possible—could improve diagnostic ...
Shinya Yokoyama, Takashi Honda, Yoji Ishizu, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Chiyoe Shirota, Takahisa Tainaka, Satoshi Makita, Masanao Nakamura, Hiroo Uchida, Hiroki Kawashima   +11 more
wiley   +1 more source

Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome‐Related Disorders

Hepatology Research, EarlyView.
It is speculated that the onset of obesity‐related diseases follows the sequence of obesity → SLD → MetS‐related diseases. In this study, the contribution of SLD to each MetS‐related disease was large for T2D and hypertension and SLD contributed to the onset and new onset of the disease by the 7‐year follow‐up.
Yoshihiro Kamada, Makoto Fujii, Hitoshi Nishizawa, Shiro Fukuda, Makoto Yamada, Iichiro Shimomura, Eiji Miyoshi   +6 more
wiley   +1 more source

Associations of Intraoperative Hypotension and Vasopressor Administration With Postoperative Acute Kidney Injury in Children Undergoing Liver Transplantation: A Retrospective Cohort Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Both intraoperative hypotension (IOH) and vasopressor administration are independently associated with postoperative acute kidney injury (AKI) in adults undergoing major noncardiac surgery. Whether these associations extend to children undergoing major noncardiac surgery, such as liver transplantation, remains unknown.
Theodora Wingert, Kelly Feldman, Tiffany Williams, Amelie Delaporte, Matthew Lum, Tristan Grogan, Christine Nguyen‐Buckley, Alexandre Joosten   +7 more
wiley   +1 more source