Results 141 to 150 of about 1,208 (169)

Quinoa Improves Non‐Alcoholic Fatty Liver Disease by Regulating the Ras‐PLD Pathway to Activate Autophagy

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Quinoa alleviates liver injury, glucose/lipid metabolic disorders, and insulin resistance in high‐fat diet‐induced NAFLD mice. Mechanistically, it acts by inhibiting the Ras‐PLD signaling pathway, activating autophagy, and regulating key related protein/gene expressions, as validated via network pharmacology, transcriptomics, and in vivo experiments ...
Yuelin Zhang, Zhengting Liang, Jiaxian Liu, Xianjie Zhen, Ruijie Liu, Xiaohong Luo, Guangjian Jiang   +6 more
wiley   +1 more source

Hibiscus rosa‐sinensis: A Multifunctional Flower Bridging Nutrition, Medicine, and Molecular Therapeutics

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
H. rosa‐sinensis bioactives modulate oxidative and inflammatory pathways. Myricetin and rutin show strong α‐glucosidase and SOD binding affinity. Exhibits safe, multifunctional use in health, food and nutraceuticals. ABSTRACT Hibiscus rosa‐sinensis, commonly known as the shoe flower, thrives in tropical and subtropical regions across South China, Asia,
Hassan Raza, Muhammad Tauseef Sultan, Khalil Ahmad, Muhammad Maaz, Shehnshah Zafar, Ahmad Mujtaba Noman, Entessar Mohammad Al Jbawi   +6 more
wiley   +1 more source

Coffee Consumption and Risk of Incident Gastrointestinal Disease: A Large Prospective Cohort Study

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
In a large prospective cohort, unsweetened coffee consumption demonstrated a U‐shaped association with a reduced risk of multiple gastrointestinal diseases and attenuated genetic susceptibility, whereas adding sweeteners, particularly artificial ones, diminished these protective effects.
Shenxuan Zhou, Fulan Hu, Zhiping Long, Hao Huang, Dapeng Li, Minjie Chu, Lei Zhang   +6 more
wiley   +1 more source

Antioxidant and Hepatotoxicity Ameliorative Potential of Mentha canadensis Leaves Against Paracetamol‐Induced Hepatic Damage in Mice

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study demonstrates the hepatoprotective potential of M. canadensis leaf methanolic extract (MCLME), through its antioxidant and anti‐inflammatory activities, against paracetamol‐induced liver injury in mice. MCLME significantly reduced serum liver biomarkers, restored glutathione and IL‐6 levels, and improved hepatic histology, indicating membrane
Asma Ul Husna Biswas, Tasnima Kamal, Azmin Akter, Sharmin Akter, Azadur Rahman Bhuiyan, Zinnat Ara Moni, Abdul Auwal, Nitai Roy, Shakhawoat Hossain, Farhadul Islam   +9 more
wiley   +1 more source

Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

iNew Medicine, Volume 1, Issue 1, December 2025.
The role of extracellular vesicles (EVs) in the progression of nonalcoholic fatty liver disease (NAFLD). Donor cells release EVs containing various molecules such as cholesterol, ceramide, sphingomyelin, miRNA, DNA, proteins, and lipids. These EVs are taken up by multiple recipient cells including Kupffer cells, adipocytes, β cells, adipose tissue ...
Yunsheng Dong, Lei Xiong, Nina Zhu, Zihan Wang, Hanqi Xia, Chen Cheng, Jianshang Huang, Yiran Han, Abduxukur Rahman, Junhao Zhao, Chonggui Jiang, Li Zuo, Hua Wang   +12 more
wiley   +1 more source

In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, Volume 45, Issue 12, Page 2641-2653, December 2025.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Association of maternal biliary disease with hepatopancreatobiliary morbidity in offspring

Journal of Pediatric Gastroenterology and Nutrition, Volume 81, Issue 6, Page 1422-1430, December 2025.
Abstract Objectives Maternal biliary disease is common, but the link with offspring hepatopancreatobiliary disease has not been studied. We assessed the association between maternal biliary disease and pediatric hepatopancreatobiliary morbidity. Methods We conducted a retrospective cohort study of 1,271,864 children born between 2006 and 2022 in Quebec,
Nathalie Auger, Angela Magri, Sarit Kang‐Auger, Gabrielle Jutras, Jessica Healy‐Profitós, Marianne Bilodeau‐Bertrand, Gabriel Côté‐Corriveau   +6 more
wiley   +1 more source

Initial Clinical Experience With the Oral Cholate Challenge Test: Results From the 2023–2024 Early Access Program

Liver International Communications, Volume 6, Issue 4, December 2025.
ABSTRACT The oral cholate challenge test of liver health, intended for use in compensated advanced chronic liver disease, was launched through an Early Access Program (EAP) in 2023–2024. Tests were provided to 16 clinicians at five liver centres across the US. The tested patients (n = 129) represented a range of etiologies and stages of disease.
Stuart C. Gordon, James Burton, Bhaktasharan Patel, for the EAP Participants   +3 more
wiley   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

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