Results 81 to 90 of about 1,208 (169)

Increased incidence, survival, and registration quality of primary hepato‐pancreato‐biliary cancers in the Netherlands Cancer Registry

International Journal of Cancer, EarlyView.
What's New? Primary hepato‐pancreato‐biliary cancers have poor prognosis and their reporting often scores low on standard data quality indicators in population‐based cancer registries. This comprehensive evaluation of cases in the Netherlands Cancer Registry shows that both the incidence and survival rates of most primary hepato‐pancreato‐biliary ...
Lydia G. van der Geest, Marianne van der Mark, Joanne Verheij, Arantza Farina Sarasqueta, Judith de Vos‐Geelen, Marc G. Besselink, Vincent E. de Meijer, Ignace H. J. T. de Hingh, Bert A. Bonsing, Philip R. de Reuver, Francois E. J. A. Willemssen, Pauline A. J. Vissers, Otto Visser, the Dutch Pancreatic Cancer Group and the Dutch Hepatocellular & Cholangiocarcinoma Group   +13 more
wiley   +1 more source

Validation of Coding Algorithms for the Identification of Patients with Primary Biliary Cirrhosis Using Administrative Data

Canadian Journal of Gastroenterology, 2010
BACKGROUND: Large-scale epidemiological studies of primary biliary cirrhosis (PBC) have been hindered by difficulties in case ascertainment.
Robert P Myers, Abdel Aziz M Shaheen, Andrew Fong, Alex F Wan, Mark G Swain, Robert J Hilsden, Lloyd Sutherland, Hude Quan   +7 more
doaj   +1 more source

Protein Induced by Vitamin K Absence or Antagonist‐II: Significantly Elevated in Obstructive Jaundice and Sepsis Patients Without Hepatocellular Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
The PIVKA‐II produced by HCC may differ from that produced by obstructive jaundice and sepsis. Given that serum PIVKA‐II levels are abnormally elevated in patients with obstructive jaundice and sepsis, the results should be interpreted with caution in patients with hepatocellular carcinoma combined with these diseases. ABSTRACT Background PIVKA‐II is a
Ke Zhang, Xiarui Ye, Xianran Fu
wiley   +1 more source

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt, Kirsteen M. Donaldson, Jeevan R. Kunta, Joseph M. Custodio   +3 more
wiley   +1 more source

Early Definitive Surgery for Congenital Biliary Dilatation in Children Is Associated With Lower Morbidity: Comparison of Infant and School‐Age Children From 231 Consecutive Cases in a Multicenter Study in the Kyushu Area of Japan During the Past Decade

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Purpose There has been little discussion on the differences in characteristics and long‐term outcomes of congenital biliary dilation (CBD) by age group. Methods We conducted a regional multicenter study to investigate all pediatric cases of CBD in the Kyushu area of Japan over the past decade.
Masakazu Murakami, Koshiro Sugita, Shohei Maeda, Kina Miyoshi, Yusuke Yamane, Taichiro Kosaka, Shun Onishi, Makoto Hayashida, Toshiharu Matsuura, Kimio Asagiri, Motofumi Torikai, Yukihiro Tatekawa, Takeshi Yamanouchi, Taizo Hibi, Tatsuro Tajiri, Satoshi Ieiri   +15 more
wiley   +1 more source

Hepatopulmonary syndrome in children and adolescents with portal hypertension in Brazil: A multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To describe the clinical and laboratory characteristics and outcomes of pediatric hepatopulmonary syndrome (HPS) secondary to portal hypertension (PH) in Brazil. Methods Fifty‐four pediatric patients diagnosed with PH and HPS according to the European Respiratory Society criteria were included in this multicenter retrospective study.
Leticia Drumond Alberto, Eleonora Druve Tavares Fagundes, Adriana Teixeira Rodrigues, Thaís Costa Nascentes Queiroz, Gustavo Valverde de Castro, Carlos Oscar Kieling, Sandra Maria Gonçalves Vieira, Natália Lamounier dos Martires Guerra, Natascha Silva Sandy, Gilda Porta, Irene Kazue Miura, Maria Ângela Bellomo Brandão, Gabriel Hessel, Adriana Maria Alves de Tommaso, Alexandre Rodrigues Ferreira   +14 more
wiley   +1 more source

DOCK8 deficiency presenting with sclerosing cholangitis, raised immunoglobulin E, and bronchiectasis: A fatal pediatric case report

JPGN Reports, EarlyView.
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare autosomal recessive primary immunodeficiency. Patients with DOCK8 deficiency typically present at early age with allergic manifestations, cutaneous and respiratory infections, raised immunoglobulin E, and they have an increased risk of developing malignancies.
Natalia Nedelkopoulou, Kelechi Ugonna, Stephen Hughes, Sanjay Rajwal, Marumbo Mtegha   +4 more
wiley   +1 more source

Autoantibody signatures in children with celiac disease, juvenile idiopathic arthritis, and polyautoimmunity

JPGN Reports, EarlyView.
Abstract Objective To determine if multiplex autoantibody arrays can identify novel biomarker signatures in children with one or multiple autoimmune diseases (polyautoimmunity). Methods Plasma collected from children (18 years or younger) in the Boston Children's Hospital Precision Link Biobank for Health Discovery between January 2007 and June 2021 ...
Nan Du, Denis Chang, Madison Wong, Jay R. Thiagarajah, Erin Janssen, Lauren A. Henderson, Krishnan Raghunathan, Jocelyn A. Silvester   +7 more
wiley   +1 more source

Liver Stiffness Characterization of OGTLKO Mouse Model of Progressive Liver Fibrosis

Journal of Ultrasound in Medicine, EarlyView.
Objectives O‐GlcNAcylation plays a key regulatory role in hepatic physiology, and its disruption leads to fibrosis in liver‐specific OGT knockout mice (OGTLKO), making this model valuable for studying advanced metabolic dysfunction‐associated steatohepatitis (MASH).
Gilles Renault, Lenin Chinchilla, Lourdes Massengo, Pierre Monbernard, Fadila Benhamed, Marion Regnier, Raphael Denis, Catherine Postic, Anthony Novell, Jean‐Luc Gennisson   +9 more
wiley   +1 more source

Phase IIb Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrahepatic cholangiocarcinoma (ICC) patients signed the informed consents.
Zu‐Yau Lin, Ming‐Lun Yeh, Po‐Cheng Liang, Shinn‐Cherng Chen, Chung‐Feng Huang, Jee‐Fu Huang, Chia‐Yen Dai, Ming‐Lung Yu, Wan‐Long Chuang   +8 more
wiley   +1 more source