Results 141 to 150 of about 9,207,506 (367)

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

open access: yesAdvanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li   +8 more
wiley   +1 more source

DomainScope: A disease network based on protein domain connections [PDF]

open access: yesarXiv, 2019
Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv  

Maternal regulation of biliary disease in neonates via gut microbial metabolites. [PDF]

open access: yesNat Commun, 2022
Jee JJ   +23 more
europepmc   +1 more source

Incidental gallbladder cancer: what is the prevalence and how do we perform cholecystectomy for presumably benign biliary disease? [PDF]

open access: yesRev Col Bras Cir, 2023
Silva DAGD   +6 more
europepmc   +1 more source

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