Diagnostic and Therapeutic Indications for Endoscopic Ultrasound (EUS) in Patients with Pancreatic and Biliary Disease-Novel Interventional Procedures. [PDF]
Curr Oncol, 2022 Prager M +3 more
europepmc +1 more source
KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression
Advanced Science, EarlyView.Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao +9 more
wiley +1 more source
Can Lemborexant for Insomnia Prevent Delirium in High-Risk Patients with Pancreato-Biliary Disease after Endoscopic Procedures under Deep Sedation? [PDF]
J Clin Med, 2022 Ogura T +10 more
europepmc +1 more source
Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment [PDF]
, 2017 A Rai +30 more
core +3 more sources
Global, regional, and national quality of care of gallbladder and biliary tract cancer: a systematic analysis for the global burden of disease study 1990–2017 [PDF]
, 2021 Javad Khanali +14 more
openalex +1 more source
Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells
Advanced Science, EarlyView.This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama +17 more
wiley +1 more source
Mutated Pkhd1 alone is sufficient to cause autoimmune biliary disease on the nonobese diabetic (NOD) genetic background. [PDF]
Immunogenetics, 2023 Adams DE +4 more
europepmc +1 more source
Advanced Science, EarlyView.It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li +9 more
wiley +1 more source
Advanced Science, EarlyView.The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang +22 more
wiley +1 more source
Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis
Advanced Science, EarlyView.Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park +5 more
wiley +1 more source