Results 141 to 150 of about 238,222 (362)

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Structural insights into manganese-dependent arylsulfatase from Enterococcus faecium and its catalytic promiscuity

mBio
Catalytic promiscuity, wherein enzymes catalyze multiple distinct reactions by stabilizing various transition states, is well documented in the alkaline phosphatase superfamily.
Lulu Guo, Xuanjia Dong, Zetao Hu, Ling Zeng, Zhaohui Jin, Lin Jiang, Wenting Dai, Jinbiao Ma, Shili Chen, Ying Huang   +9 more
doaj   +1 more source

Maternal regulation of biliary disease in neonates via gut microbial metabolites. [PDF]

Nat Commun, 2022
Jee JJ, Yang L, Shivakumar P, Xu PP, Mourya R, Thanekar U, Yu P, Zhu Y, Pan Y, Wang H, Duan X, Ye Y, Wang B, Jin Z, Liu Y, Cao Z, Watanabe-Chailland M, Romick-Rosendale LE, Wagner M, Fei L, Luo Z, Ollberding NJ, Tang ST, Bezerra JA.   +23 more
europepmc   +1 more source

Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment [PDF]

, 2017
A Rai, AG Tolcher, AX Zhu, Caio Max S Rocha-Lima, David Portnoy, DP Brooks, E Gabriela Chiorean, E Suzuki, J Albores-Saavedra, J Nelson, J Valle, JE Rogers, JF Guion-Dussere, Jitendra Gandhi, L Goyal, M Yanagisawa, Manik Amin, NV Rajeshkumar, NV Rajeshkumar, P Papakostas, R Pazdur, Richard Kim, RK Jain, RL Siegel, S He, SC Lee, SY Oh, T Sasaki, T Walter, Tao Song, William P Harris   +30 more
core   +3 more sources

Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) serve as externally controlled, MRI‐activated theranostic agents for targeted cancer therapy by inducing electric field‐based ablation in solid tumors. MENPs enable simultaneous precise tumor ablation and MRI signal modulation, allowing real‐time treatment monitoring and prediction of therapeutic outcomes with no ...
John Michael Bryant, Max Shotbolt, Emmanuel Stimphil, Victoria Andre, Elric Zhang, Veronica Estrella, Kazim Husain, Joseph Weygand, Doug Marchion, Alex Sebastian Lopez, Dominique Abrahams, Shawnus Chen, Mostafa Abdel‐Mottaleb, Skye Conlan, Ibrahim Oraiqat, Vaseem Khatri, Jose Alejandro Guevara, Shari Pilon‐Thomas, Gage Redler, Kujtim Latifi, Natarajan Raghunand, Kosj Yamoah, Sarah Hoffe, James Costello, Jessica M. Frakes, Ping Liang, Robert A. Gatenby, Mokenge Malafa, Sakhrat Khizroev   +28 more
wiley   +1 more source

Correction: TRPM8 contributes to liver regeneration via mitochondrial energy metabolism mediated by PGC1α

Cell Death and Disease, 2023
Xiaohua Lei, Qiang Liu, Wei Qin, Qing Tong, Zhenghao Li, Wendi Xu, Guoxing Liu, Jie Fu, Ju Zhang, Tao Kuang, Yaoli Shao, Chun Liu, Yu Fang, Zhenyu Cao, Likun Yan, Zhiqiang Liu, Siyuan Liu, Hirofumi Yamamoto, Masaki Mori, Xin M. Liang, Xundi Xu   +20 more
doaj   +1 more source

Endoscopic ultrasound-guided antegrade stenting for benign biliary disease in an elderly patient with altered anatomy (Roux-en-Y). [PDF]

Endoscopy, 2023
Luna-Rodriguez D, Maisterra S, Garcia-Sumalla A, Puigcerver-Mas M, Gornals JB.   +4 more
europepmc   +1 more source

Retrograde biliary stenting in patients with pancreatobiliary diseases

, 2013
I M Sayfutdinov, Л Е Славин, А. Ф. Галимзянов, Р. Т. Зимагулов   +3 more
openalex   +2 more sources

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Liver and Biliary Disease of Pregnancy and Anesthetic Implications: A Review. [PDF]

Anesth Analg, 2021
Hansen JD, Perri RE, Riess ML.
europepmc   +1 more source