Results 11 to 20 of about 238,222 (362)

The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1

Journal of Translational Medicine, 2023
Background Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pathway, and its abnormality leads to
Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu, Ying Huang   +9 more
doaj   +1 more source

KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H ₂S axis and contributes to pancreatic cancer growth

Acta Biochimica et Biophysica Sinica, 2022
In pancreatic cancer, KRAS G12D can trigger pancreatic cancer initiation and development. Rapid tumor growth is often accompanied by excess intracellular reactive oxygen species (ROS) production, which is unfavorable to tumor.
Fan Kun, Zhang Shulong, Ni Xiaojian, Shen Sheng, Wang Jiwen, Sun Wentao, Suo Tao, Liu Han, Ni Xiaoling, Liu Houbao   +9 more
doaj   +1 more source

lncRNA RP11-147L13.8 suppresses metastasis and chemo-resistance by modulating the phosphorylation of c-Jun protein in GBC

Molecular Therapy: Oncolytics, 2021
Long non-coding RNAs (lncRNAs) have been identified as critical contributors in tumor progression for many types of cancer. However, their functions in gallbladder cancer (GBC) have not been systematically clarified.
Bohao Zheng, Jiwen Wang, Kun Fan, Wentao Sun, Wenze Wan, Zhihui Gao, Xiaojian Ni, Dexiang Zhang, Xiaoling Ni, Tao Suo, Han Liu, Houbao Liu, Sheng Shen   +12 more
doaj   +1 more source

Retained stone retrieval basket causing chronic pancreatitis: a case report

Frontiers in Surgery, 2023
BackgroundEndoscopic retrograde cholangiopancreatography is a common procedure performed for choledocholithiasis and gallstone pancreatitis. Although a relatively low risk procedure, it is not without its complications.
James Wai Kit Lee, James Wai Kit Lee, James Wai Kit Lee, Ming Yuan Tan, Calvin Koh, Shridhar Ganpathi Iyer, Shridhar Ganpathi Iyer, Yujia Gao, Yujia Gao   +8 more
doaj   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
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Improved long‐term outcomes after innovative preoperative evaluation and conception of precise surgery for gallbladder cancer

Cancer Medicine, 2023
Background Three‐dimensional visualization preoperative evaluation (3D‐VPE) and enhanced recovery after surgery (ERAS) have been suggested to improve outcomes of cancer surgery in patients, yet little is known regarding their clinical benefit in patients
Zi‐Yao Jia, Yi‐Di Zhu, Xiang‐Song Wu, Jing‐Xiao Yang, Wen‐Guang Wu, Xu‐An Wang, Min He, Hui Wang, Lin‐Hua Yang, Jie Zhang, Xue‐Chuan Li, Lu Zou, Huai‐Feng Li, Fei Zhang, Run‐Fa Bao, Xu‐Ya Cui, Xiao‐Ling Song, Wei Chen, Wei Gong, Mao‐Lan Li, Ying‐Bin Liu   +20 more
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The NOD Mouse Beyond Autoimmune Diabetes

Frontiers in Immunology, 2022
Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the pathophysiology of this disease shares many similarities with human type 1 diabetes. Since its generation in 1980, the NOD mouse, derived from the Cataract Shinogi strain,
Anne-Marie Aubin, Anne-Marie Aubin, Félix Lombard-Vadnais, Félix Lombard-Vadnais, Roxanne Collin, Roxanne Collin, Roxanne Collin, Holly A. Aliesky, Holly A. Aliesky, Sandra M. McLachlan, Sandra M. McLachlan, Sylvie Lesage, Sylvie Lesage   +12 more
doaj   +1 more source

Pediatric Liver Transplantation: Then and Now [PDF]

, 2020
This paper reviews the past 50 years of liver transplantation in children from the perspective of patient demographics, perioperative patient management, surgical techniques, immunosuppression and patient ...
Banh, DPT, Carullo, PC, Davis, PJ, Tran, LT, Vitu, C   +4 more
core   +1 more source

Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholagnitis [PDF]

, 2018
The non-invasive differentiation of malignant and benign biliary disease is a clinical challenge. Carbohydrate antigen 19-9 (CA19-9), leucine-rich α2-glycoprotein (LRG1), interleukin 6 (IL6), pyruvate kinase M2 (PKM2), cytokeratin 19 fragment (CYFRA21.1)
Blyuss, O, Cuenco, J, Dawnay, A, Kazarian, A, Manns, MP, Menon, U, Pereira, SP, Timms, JF, Wehnert, N, Whitwell, HJ   +9 more
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Pathologic analysis of liver transplantation for primary biliary cirrhosis [PDF]

, 1988
A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other ...
Ballardini, Baum, Berg, Bernuau, Demetris, Demetris, Demetris, Demetris, Detre, Epstein, Epstein, Esquivel, Fennell, Fung, Haagsma, Iwatsuki, James, MacSween, McFarlane, McFarlane, Neuberger, Popper, Portmann, Portmann, Portmann, Vento   +25 more
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