Results 261 to 270 of about 9,207,506 (367)
Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives
Chemistry &Biodiversity, EarlyView.ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos +8 more
wiley +1 more source
Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology
ChemBioChem, EarlyView.This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda +2 more
wiley +1 more source
Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes
ChemElectroChem, EarlyView.This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský +5 more
wiley +1 more source
Older adults living with gastrointestinal cancers in 2021
Cancer Communications, EarlyView.
Pojsakorn Danpanichkul +15 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Steroid photoreactivity was a major topic in the last century. This study revisits it by exploring the photochemistry of Δ1‐keto‐steroids, offering an efficient method to modify the classic steroid 6/6/6/5 ring system. This approach enables the transformation of accessible steroids into rare ones, demonstrated by synthesizing 5,6‐dihydro‐ophiopogonol A
Chiara Maioli +8 more
wiley +1 more source
Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”
ChemMedChem, EarlyView.This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley +1 more source