Results 31 to 40 of about 238,222 (362)

PI3K-CCL2-CCR2-MDSCs axis: A potential pathway for tumor Clostridia-promoted CD 8+ T lymphocyte infiltration in bile tract cancers

open access: yesNeoplasia: An International Journal for Oncology Research, 2023
Background: Most patients with resected bile tract cancers (BTCs) survive for less than 5 years; however, some achieve better prognosis. The tumor microbiome can improve survival by regulating the tumor immune microenvironment. However, whether the tumor
Wen-Jie Ma   +7 more
doaj   +1 more source

Cholecystectomy for Complicated Gallbladder and Common Biliary Duct Stones: Current Surgical Management

open access: yesFrontiers in Surgery, 2020
Gallstone disease accounts for the vast majority of acute surgical admissions in the UK, with a major treatment being cholecystectomy. Practice varies significantly as to whether surgery is performed during the acute symptomatic phase, or after a period ...
Yanna Argiriov   +3 more
doaj   +1 more source

Effect of Hyperthermic Intraperitoneal Perfusion Chemotherapy Combined with Radical Surgery and Capecitabine on Stage III Gallbladder Cancer

open access: yesCanadian Journal of Gastroenterology and Hepatology, 2021
Purpose. The aim of the study was to investigate the effect of hyperthermic intraperitoneal perfusion chemotherapy (HIPEC) combined with radical surgery and capecitabine on stage III gallbladder cancer. Method.
Sulai Liu   +8 more
doaj   +1 more source

Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis

open access: yesiScience
Summary: Abnormal mTORC1 activation by the lysosomal Ragulator complex has been implicated in cancer and glycolytic metabolism associated with drug resistance. Fasting upregulates RNF152 and mediates the metabolic status of cells.
Ying Tao   +13 more
doaj   +1 more source

Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia [PDF]

open access: yes, 1976
In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there
Hansbrough, JF   +5 more
core   +1 more source

Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?

open access: yesFrontiers in Endocrinology
BackgroundGallbladder mixed neuroendocrine-non-neuroendocrine neoplasm generally consists of a gallbladder neuroendocrine tumor and a non-neuroendocrine component.
Ya-Fei Hu   +23 more
doaj   +1 more source

SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes

open access: yesCancer Medicine, 2023
Background Hepatocellular carcinoma (HCC) has a poor prognosis and new effective treatments are needed. SLC12A5 plays important roles in multiple complex pathological states and is overexpressed in a variety of malignancies.
Qing Tong   +6 more
doaj   +1 more source

Liver transplantation in primary biliary cirrhosis: Risk assessment and 11-year follow-up [PDF]

open access: yes, 2000
Background/Aims: Liver transplantation (LTx) is the only established treatment in patients with end-stage primary biliary cirrhosis (PBC). Although short-term survival after LTx in this group of patients is usually good, few data exist on the long-term ...
Beuers, Ulrich   +8 more
core   +2 more sources

The microbiota of the bilio-pancreatic system: A cohort, STROBE-compliant study [PDF]

open access: yes, 2019
Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes.
Agrusa A.   +8 more
core   +1 more source

The anticancer activity of bile acids in drug discovery and development

open access: yesFrontiers in Pharmacology
Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system.
Weijian Li   +28 more
doaj   +1 more source

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