Results 101 to 110 of about 991,994 (269)

Biliary tract cancers: current knowledge, clinical candidates and future challenges

open access: yesCancer Management and Research, 2019
Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition.
N. Tariq, M. McNamara, J. Valle
semanticscholar   +1 more source

A Bioinformatic Approach Validated Utilizing Machine Learning Algorithms to Identify Relevant Biomarkers and Crucial Pathways in Gallbladder Cancer [PDF]

open access: yesarXiv
Gallbladder cancer (GBC) is the most frequent cause of disease among biliary tract neoplasms. Identifying the molecular mechanisms and biomarkers linked to GBC progression has been a significant challenge in scientific research. Few recent studies have explored the roles of biomarkers in GBC.
arxiv  

A phase 2 trial of regorafenib as a single agent in patients with chemotherapy‐refractory, advanced, and metastatic biliary tract adenocarcinoma

open access: yesCancer, 2018
Biliary tract cancers are rare, aggressive neoplasms. Most patients present with advanced/unresectable or metastatic disease at diagnosis, and no second‐line regimen has demonstrated clinical benefit.
Weijing Sun   +9 more
semanticscholar   +1 more source

Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies.

open access: yesJournal of the National Cancer Institute, 2019
BACKGROUND Tobacco and alcohol are well-established risk factors for numerous cancers, yet their relationship to biliary tract cancers remains unclear. METHODS We pooled data from 26 prospective studies to evaluate associations of cigarette smoking and
Emma E. McGee   +56 more
semanticscholar   +1 more source

Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract

open access: yesScientific Reports, 2019
Despite considerable recent insight into the molecular phenotypes and type 2 innate immune functions of tuft cells in rodents, there is sparse knowledge about the region-specific presence and molecular phenotypes of tuft cells in the human digestive ...
B. Schütz   +6 more
semanticscholar   +1 more source

Tract orientation mapping for bundle-specific tractography [PDF]

open access: yesarXiv, 2018
While the major white matter tracts are of great interest to numerous studies in neuroscience and medicine, their manual dissection in larger cohorts from diffusion MRI tractograms is time-consuming, requires expert knowledge and is hard to reproduce. Tract orientation mapping (TOM) is a novel concept that facilitates bundle-specific tractography based
arxiv  

LOXL1 exerts oncogenesis and stimulates angiogenesis through the LOXL1-FBLN5/αvβ3 integrin/FAK-MAPK axis in ICC

open access: yesMolecular Therapy: Nucleic Acids, 2021
Aberrant expression of lysyl oxidase-like 1 (LOXL1) reportedly leads to fibrous diseases. Recent studies have revealed its role in cancers. In this study, we observed an elevated level of LOXL1 in the tissues and sera of patients with intrahepatic ...
Ruiyan Yuan   +14 more
doaj  

HAMLET: Hierarchical Harmonic Filters for Learning Tracts from Diffusion MRI [PDF]

open access: yesarXiv, 2018
In this work we propose HAMLET, a novel tract learning algorithm, which, after training, maps raw diffusion weighted MRI directly onto an image which simultaneously indicates tract direction and tract presence. The automatic learning of fiber tracts based on diffusion MRI data is a rather new idea, which tries to overcome limitations of atlas-based ...
arxiv  

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