Results 101 to 110 of about 83,082 (294)

Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open‐Label Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Imlunestrant (LY3484356) is a next‐generation orally bioavailable selective estrogen receptor degrader being investigated for the treatment of estrogen receptor–positive advanced breast and endometrial cancers. This Phase 1, open‐label, 2‐part study evaluated the disposition and absolute bioavailability of [14C]‐imlunestrant in 16 US‐based ...
Amita Datta‐Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Vivian Rodriguez Cruz, Kenneth Cassidy   +6 more
wiley   +1 more source

BILIARY TRACT HEMORRHAGE

, 1950
Harry Hyland Kerr, Maurice Mensh, Ernest A. Gould   +2 more
openalex   +2 more sources

Microbiome‐Informed Dosing: Exploring Gut Microbial Communities Impact on Mycophenolate Enterohepatic Circulation and Therapeutic Target Achievement

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacomicrobiomics is an emerging field due to important microbiome effects on pharmacokinetics and clinical outcomes. However, the application of this knowledge remains limited. Mycophenolic acid (MPA) is the primary active metabolite of the immunosuppressant, mycophenolate mofetil (MMF).
Abdelrahman Saqr, Shen Cheng, Mahmoud Al‐Kofahi, Christopher Staley, Pamala A. Jacobson   +4 more
wiley   +1 more source

Drug reactions characterized by cholestasis associated with intrahepatic biliary tract obstruction

, 1957
Alexander B. Gutman
openalex   +1 more source

Ampicillin Levels in Human Bile in the Presence of Biliary Tract Disease [PDF]

, 1969
P. R. Mortimer, Diane Mackie, Stephen N. Haynes   +2 more
openalex   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

DendroX: multi-level multi-cluster selection in dendrograms

BMC Genomics
Background Cluster heatmaps are widely used in biology and other fields to uncover clustering patterns in data matrices. Most cluster heatmap packages provide utility functions to divide the dendrograms at a certain level to obtain clusters, but it is ...
Feiling Feng, Qiaonan Duan, Xiaoqing Jiang, Xiaoming Kao, Dadong Zhang   +4 more
doaj   +1 more source

Think highly of immunoglobulin G4‐related chronic rhinosinusitis as a clinical entity in immunoglobulin G4‐related disease

Eye &ENT Research, EarlyView.
Abstract IgG4‐related chronic rhinosinusitis (IgG4‐related CRS) is gaining recognition among various specialized physicians. As a systemic disease involving multiple organs, IgG4‐related CRS is still not widely recognized as an independent clinical entity. Given the complexity of diagnosing autoimmune‐related multisystem diseases, early recognition and
Lianqi Wan, Luo Zhang, Yingshi Piao, Yuan Zhang   +3 more
wiley   +1 more source

BENIGN EXTRAHEPATIC BILIARY TRACT OBSTRUCTION

, 1951
Robert D. OʼMalley, Arthur H. Aufses, Allen O. Whipple   +2 more
openalex   +2 more sources

Gut Microbiota‐Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High‐Altitude

Exploration, EarlyView.
Long‐term migration to high‐altitude areas can readily result in chronic high‐altitude diseases; however, effective prevention and treatment methods are currently lacking. This study employed a multi‐omics approach, integrating metagenomics and metabolomics, to discover and validate that the decreased abundance of Veillonella rogosae, Streptococcus ...
Yongqiang Zhou, Zhexin Ni, Jingjing Liu, Dezhi Sun, Pan Shen, Xi Chen, Gaofu Li, Zhijie Bai, Yangyi Hu, Ningning Wang, Rui Wang, Lina Guan, Yihao Wang, Xianglin Tang, Yungang Lu, Baokun He, Haitao Lu, Wei Zhou, Yue Gao   +18 more
wiley   +1 more source