Results 41 to 50 of about 1,090,016 (327)
Molecular profile of BRCA-mutated biliary tract cancers
ESMO Open, 2020 Introduction Prognosis of biliary tract cancers (BTC) remains dismal and novel treatment strategies are needed to improve survival. BRCA mutations are known to occur in BTC but their frequency and the molecular landscape in which they are observed in ...
G. Spizzo +21 more
semanticscholar +1 more source
Hepatology, 2021 Biliary tract cancer is a group of highly aggressive malignant disorders, yet risk factors are poorly understood. In this study, we aim to assess whether prolonged use of proton pump inhibitors (PPIs) increases the risk of incident biliary tract ...
Habiba Kamal +3 more
semanticscholar +1 more source
Hepatic progenitor cells from adult human livers for cell transplantation. [PDF]
, 2008 Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells ...
Aurich, H. +10 more
core +1 more source
Circulating Tumor DNA in Biliary Tract Cancer: Current Evidence and Future Perspectives
Cancer Genomics & Proteomics, 2020 Peripheral blood of cancer patients “physiologically” presents cells and cellular components deriving from primary or metastatic sites, including circulating tumor cells (CTCs), circulating free DNA (cfDNA) and exosomes containing proteins, lipids and ...
A. Rizzo +3 more
semanticscholar +1 more source
Cancer Epidemiology, Biomarkers and Prevention, 2021 Background: Few population-based studies have examined incidence and mortality of cancers of the biliary tract, including intrahepatic bile duct, extrahepatic bile duct, ampulla of Vater, and overlapping or other lesions of the biliary tract in one study.
Taylor D. Ellington +5 more
semanticscholar +1 more source
Correlation of mechanical factors and gallbladder pain [PDF]
, 2008 Acalculous biliary pain occurs in patients with no gallstones, but is similar to that experienced by patients with gallstones. Surgical removal of the gallbladder (GB) in these patients is only successful in providing relief of symptoms to about half of ...
Bird, N.C. +6 more
core +3 more sources
“Steinstrasse” in the Biliary Tract
The Eurasian Journal of Medicine, 2017 The presence of a stone or stones within the common bile duct (CBD) is known as choledocholithiasis. Choledocholithiasis is reported in 3%-22% of patients undergoing cholecystectomies [1]. A confirmatory diagnosis of choledocholithiasis is made using advanced imaging, including magnetic resonance cholangiopancreatography and endoscopic retrograde ...
openaire +4 more sources
JAMA Oncology, 2019 Importance Administration of gemcitabine-cisplatin, the current standard therapy for advanced biliary tract cancers, results in median progression-free survival and overall survival of 8.0 and 11.7 months, respectively.
R. Shroff +12 more
semanticscholar +1 more source
Immunotherapy in Advanced Biliary Tract Cancers
Cancers, 2021 Simple Summary A new era has emerged in oncology in the last ten years with the development of immune therapies. However, single-agent immune therapy such as immune checkpoint inhibitors seems to have a limited clinical activity in biliary tract cancers ...
A. Boilève +5 more
semanticscholar +1 more source
iScienceSummary: Abnormal mTORC1 activation by the lysosomal Ragulator complex has been implicated in cancer and glycolytic metabolism associated with drug resistance. Fasting upregulates RNF152 and mediates the metabolic status of cells.
Ying Tao +13 more
doaj +1 more source