Results 31 to 40 of about 575,936 (265)

Pathology of Biliary Tract Cancers

, 2022
Biliary tract cancers are highly malignant tumors that comprise bile duct cancers (so called cholangiocarcinoma, CCA) and gallbladder carcinomas. Based on their anatomical location, bile duct cancers fall into two main categories: intrahepatic and ...
Scarpa, Aldo, Simbolo, Michele, Luchini, Claudio   +2 more
core   +1 more source

Radiological findings and surgical outcomes of pulmonary metastases originating from biliary tract carcinoma [PDF]

, 2019
Purpose: Metastasis to the lungs arising from biliary tract carcinoma (BTC) is extremely rare, and the patient characteristics and prognosis are not well known.
Nakamura, Shota, Fukui, Takayuki, Yokoi, Kohei, Kawaguchi, Koji, Taniguchi, Tetsuo   +4 more
core   +1 more source

Biliary drainage in malignant biliary obstruction: an umbrella review of randomized controlled trials

Frontiers in Oncology, 2023
BackgroundThere are still many controversies about biliary drainage in MBO, and we aimed to summarize and evaluate the evidence associated with biliary drainage.MethodsWe conducted an umbrella review of SRoMAs based on RCTs. Through July 28, 2022, Embase,
Yaoqun Wang, Yaoqun Wang, Ningyuan Wen, Ningyuan Wen, Xianze Xiong, Bei Li, Bei Li, Jiong Lu, Jiong Lu   +8 more
doaj   +1 more source

Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma

Journal of Translational Medicine
Background Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and characterized by desmoplastic matrix. The heterogeneity and crosstalk of tumor microenvironment remain incompletely understood.
Yan-Jie Zhong, Xi-Mei Luo, Fei Liu, Zhi-Qiang He, Si-Qi Yang, Wen-Jie Ma, Jun-Ke Wang, Yu-Shi Dai, Rui-Qi Zou, Ya-Fei Hu, Tian-Run Lv, Fu-Yu Li, Hai-Jie Hu   +12 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Short-term and Long-term Clinical Outcomes of Combined Caudate Lobectomy for Intrahepatic Cholangiocarcinoma Involving the Hepatic Hilus: A Propensity Score Analysis

Gut and Liver
Background/Aims: Extended hepatectomy combined with caudate lobe resection has been approved for the radical resection of hilar cholangiocarcinoma. There was a lack of credible research on the clinical value of caudate lobectomy (CL) for intrahepatic ...
Di Zeng, Yaoqun Wang, Ningyuan Wen, Bei Li, Nansheng Cheng, Jiong Lu   +5 more
doaj   +1 more source

Bile acid analysis in biliary tract cancer [PDF]

, 2006
The etiology of biliary tract cancer is obscure, but there are evidences that bile acid plays a role in carcinogenesis. To find the association between biliary tract cancer and bile acid, this study compared the bile acid concentration and composition ...
고준상, 박정엽, 방승민, 정재복, 박병규, 송시영   +5 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Surgical anatomy of the biliary tract [PDF]

, 2008
An intimate knowledge of the morphological, functional, and real anatomy is a prerequisite for obtaining optimal results in the complex surgery of extra and intrahepatic cholangiocarcinoma.
Castaing, Denis
core   +1 more source