Results 61 to 70 of about 157,526 (353)

Adult liver transplantation: An analysis of the early causes of death in 40 consecutive cases [PDF]

, 1986
One hundred twenty‐nine adult patients who received an orthotopic liver transplantation and survived at least 24 hr after surgery were evaluated. During the period of follow‐up, 48 of the 129 patients (37%) died.
Calne, Demetris, Dominguez, Dummer, Eggiak, Fennell, Roddy, Schroter, Shaw, Snover, Starzl, Starzl, Starzl, van Thiel, van Thiel, Wajszczuk, Williams, Zajko   +17 more
core   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Integrating bulk and single cell sequencing data to identify prognostic biomarkers and drug candidates in HBV associated hepatocellular carcinoma

Scientific Reports
Hepatitis B virus (HBV) infection is a major driver of hepatocellular carcinoma (HCC), yet the mechanisms by which HBV triggers HCC and how it interacts with the immune system remain largely undefined.
Yanjie Zhong, Antony Stalin, Yushi Dai, Zhiqiang He, Siqi Yang, Ruiqi Zou, Aoqiang Zhai, Fuyu Li, Haijie Hu   +8 more
doaj   +1 more source

Outcomes after therapeutic SBE-ERCP for choledochojejunal/hepaticojejunal anastomotic stenosis after bile duct injury

Frontiers in Surgery
BackgroundCholedochojejunal/hepaticojejunal anastomotic stenosis (CJS/HJS) is significant clinical problem associated with decreased survival postsurgery. Endoscopic retrograde cholangiopancreatography (ERCP) using single-balloon enteroscopy (SBE) is the
Yijun Shu, Yijun Shu, Yijun Shu, Pak-Lam Koo, Pak-Lam Koo, Pak-Lam Koo, Hao Weng, Hao Weng, Hao Weng, Li-Jia Pan, Li-Jia Pan, Li-Jia Pan, Ming-Zhe Weng, Ming-Zhe Weng, Ming-Zhe Weng, Ziyi Yang, Ziyi Yang, Ziyi Yang, Ming-Ning Zhao, Ming-Ning Zhao, Ming-Ning Zhao, Wen-Jie Zhang, Wen-Jie Zhang, Wen-Jie Zhang, Jun Gu, Jun Gu, Jun Gu, Wei Gong, Wei Gong, Wei Gong, Jia-Wei Mei, Jia-Wei Mei, Jia-Wei Mei, Yingbin Liu, Yingbin Liu, Yingbin Liu, Xue-Feng Wang, Xue-Feng Wang, Xue-Feng Wang   +38 more
doaj   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

SEMS vs cSEMS in duodenal and small bowel obstruction : high risk of migration in the covered stent group [PDF]

, 2013
Aim: To compare clinical success and complications of uncovered self-expanding metal stents (SEMS) vs covered SEMS (cSEMS) in obstruction of the small bowel.
Albert, Jörg Gerhard, Bechstein, Wolf Otto, Friedrich-Rust, Mireen, Sarrazin, Christoph, Trojan, Jörg, Ulrich, Frank, Waidmann, Oliver, Zeuzem, Stefan   +7 more
core   +1 more source

Burn‐Safe Biodegradable Magnetocaloric Composites for Temperature‐Controlled Biomedical Applications

Advanced Science, EarlyView.
This work investigates a magnetocaloric (Mn,Fe)2(P,Si) compound tailored for precise, self‐regulating heating in biomedical use. With a Curie temperature tuned at 43 °C, it enables therapeutic activation without overheating. Encapsulation in a composite ensures controlled temperature rise under an alternating magnetic field (AMF), with high ...
Pornpawee Uliss, Vasiliki Gkouzioti, Wuliji Hanggai, Friso Kahler, Elena Aprea, Qi Jia, Jean‐Philippe Frimat, Ekkes Brück, Clementine M. Boutry   +8 more
wiley   +1 more source

Individualized Prognostic Insights: CONUT‐GBRS for Survival Prediction in Gallbladder Cancer

Cancer Medicine
Background The most suitable prognostic prediction system for gallbladder cancer (GBC) is yet to be determined. This study aims to establish a combined score integrating preoperative patients' nutritional and immune status and pathological parameters to ...
Si‐qi Yang, Rui‐qi Zou, Yu‐shi Dai, Jun‐ke Wang, Wen‐jie Ma, Hai‐jie Hu, Fu‐yu Li   +6 more
doaj   +1 more source

The anticancer activity of bile acids in drug discovery and development

Frontiers in Pharmacology
Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system.
Weijian Li, Weijian Li, Weijian Li, Weijian Li, Lu Zou, Lu Zou, Lu Zou, Lu Zou, Shuai Huang, Huijie Miao, Huijie Miao, Huijie Miao, Huijie Miao, Ke Liu, Ke Liu, Ke Liu, Ke Liu, Yajun Geng, Yajun Geng, Yajun Geng, Yajun Geng, Yingbin Liu, Yingbin Liu, Yingbin Liu, Yingbin Liu, Wenguang Wu, Wenguang Wu, Wenguang Wu, Wenguang Wu   +28 more
doaj   +1 more source