Results 91 to 100 of about 193,970 (395)

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer

Journal for ImmunoTherapy of Cancer, 2020
Background Patients with biliary tract cancer (BTC) have poor prognosis with few treatment options. Bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of the transforming growth factor (TGF)-βRII receptor ...
C. Yoo, D. Oh, H. Choi, M. Kudo, M. Ueno, S. Kondo, Li‐Tzong Chen, M. Osada, C. Helwig, I. Dussault, M. Ikeda   +10 more
semanticscholar   +1 more source

A single‐arm, multicenter, open‐label phase 2 trial of surufatinib in patients with unresectable or metastatic biliary tract cancer

Cancer, 2021
Several clinical studies of vascular endothelial growth factor/vascular endothelial growth factor receptor (VEGF/VEGFR) therapy as a second‐line treatment for biliary tract cancer (BTC) have shown modest efficacy. In this study, surufatinib was evaluated
Jianming Xu, Y. Bai, Huichuan Sun, C. Bai, R. Jia, Yi Li, Wen-jie Zhang, Lei Liu, Cheng Huang, M. Guan, Jinghong Zhou, W. Su   +11 more
semanticscholar   +1 more source

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Advanced Science, EarlyView.
This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang, Ziling Yang, Yulu Pang, Xinyue Wu, Xinrong Zhang, Tao Zhu, Xiaoyue Ding, Wei Liu, Yuan Zhou, Pengcheng Zhang, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Chronic typhoid infection and the risk of biliary tract cancer and stones in Shanghai, China

Infectious Agents and Cancer, 2011
Previous studies have shown a positive association between chronic typhoid carriage and biliary cancers. We compared serum Salmonella enterica serovar Typhi antibody titers between biliary tract cancer cases, biliary stone cases without evidence of ...
Pruckler James, Chen Jinbo, Wang Bing-Shen, Rashid Asif, Quraishi Sabah M, Sakoda Lori C, Gao Yu-Tang, Safaeian Mahboobeh, Mintz Eric, Hsing Ann W   +9 more
doaj   +1 more source

HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples [PDF]

, 2022
Eleonora Loi, Cesare Zavattari, Alessandro Tommasi, Loredana Moi, Matteo Canale, Agnese Pò, Claudia Sabato, Ana Florencia Vega-Benedetti, Pina Ziranu, Marco Puzzoni, Eleonora Lai, Luca Faloppi, María Rullán, Juan Carrascosa, Irene Amat, Jesús Urmán, María Arechederra, Carmen Berasain, Elisabetta Ferretti, Andrea Casadei‐Gardini, Matías A. Ávila, Sergio Alonso, Mario Scartozzi, Patrizia Zavattari   +23 more
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer

Gastroenterology Research and Practice, 2016
Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy.
Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Amanda Braga Bona, Marília de Arruda Cardoso Smith, Geraldo Ishak, Paulo Pimentel Assumpção, Rommel Rodríguez Burbano, Danielle Queiroz Calcagno   +7 more
doaj   +1 more source

Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China

BMC Cancer, 2012
Background Genetic variants in inflammation-related genes have been associated with biliary stones and biliary tract cancers in previous studies. Methods To follow-up on these findings, we examined 35 single nucleotide polymorphism (SNPs) in 5 genes ...
Castro Felipe A, Koshiol Jill, Hsing Ann W, Gao Yu-Tang, Rashid Asif, Chu Lisa W, Shen Ming-Chang, Wang Bing-Shen, Han Tian-Qua, Zhang Bai-He, Niwa Shelley, Yu Kai, Zhang Hong, Chanock Stephen, Andreotti Gabriella   +14 more
doaj   +1 more source

A combined prediction model for biliary tract cancer using the prognostic nutritional index and pathological findings: a single-center retrospective study

BMC Gastroenterology, 2021
Background The prognostic nutritional index, a marker of nutritional status and systemic inflammation, is a known biomarker for various cancers. However, few studies have evaluated the predictive value of the prognostic nutritional index in patients with
Masashi Utsumi, Koji Kitada, Naoyuki Tokunaga, Takamitsu Kato, Toru Narusaka, Ryosuke Hamano, Hideaki Miyasou, Yousuke Tsunemitsu, Shinya Otsuka, Masaru Inagaki   +9 more
doaj   +1 more source