Results 111 to 120 of about 193,970 (395)

Identifying Key Questions and Challenges in Microchimerism Biology

Advanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua, Rachel C. Quilang, Katja Sallinger, Christina Athena Aktipis, Petra Arck, Diana W. Bianchi, Hyun‐Dong Chang, Henderson J. Cleaves II, Michael Eikmans, Heidi E. S. Fjeldstad, David Haig, Whitney E. Harrington, William Horsnell, Daniel P. Jacobsen, Mads Kamper‐Jørgensen, Sami B. Kanaan, Kiarash Khosrotehrani, Nathalie C. Lambert, Jane Lee Nelson, Maria B. Olsen, Tiffany D. Pan, Jelmer R. Prins, Frank A. Schildberg, Anne Cathrine Staff, Anders Ståhlberg, Ina A. Stelzer, Christopher Urbschat, Sing Sing Way, Melissa A. Wilson, Jody Ye, Thomas Kroneis, Amy M. Boddy   +31 more
wiley   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

Advanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao, Cui Zhang, Hehua Lei, Weichuan Lin, Wenkai Yu, Xin Gao, Yanmeng He, Xinzhi Li, Qingwei Xiang, Zhiwen Zhang, Weifei Luo, Andrew D. Patterson, Limin Zhang, Gang Chen   +13 more
wiley   +1 more source

Risk of Biliary Tract and Pancreatic Cancer Following Obstructive Sleep Apnea Diagnosis: Analysis of a National Health Insurance Database [PDF]

Journal of Rhinology
Background and Objectives Obstructive sleep apnea (OSA) has been associated with an increased risk of cancer in various organs. OSA is also linked to chronic inflammation in the biliary tract and pancreas, a well-established risk factor for ...
Marn Joon Park, Gyu Tae Kim, Seo Jun Kang, Kyung-Do Han, Jae Hoon Cho, Ji Ho Choi   +5 more
doaj   +1 more source

Fifteen years of clinical liver transplantation [PDF]

, 1979
Liver transplantation in humans was first attempted more than 15 yr ago. The 1-yr survival has slowly improved until it has now reached about 50%. In our experience, 46 patients have lived for at least 1 yr, with the longest survival being 9 yr. The high
Abouna, Absolon, Alper, Bechtelsheimer, Benichou, Birtch, Borel, Borel, Calne, Calne, Calne, Calne, Calne, Calne, Charles G. Halgrimson, Corman, Daloze, Demirleau, Fisch, Fonkalsrud, Fortner, Fortner, Garnier, Gerhard P.J. Schroter, Green, Groth, Groth, Hume, J. Hood, K.A. Porter, Koep, Lampe, Lawrence J. Koep, Lie, Machado, Marchioro, Martineau, McMaster, Moore, Moore, Moore, Peacock, Putnam, Richard Weil, Schroter, Schroter, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl, Wall, Welch, Williams   +65 more
core   +1 more source

Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) serve as externally controlled, MRI‐activated theranostic agents for targeted cancer therapy by inducing electric field‐based ablation in solid tumors. MENPs enable simultaneous precise tumor ablation and MRI signal modulation, allowing real‐time treatment monitoring and prediction of therapeutic outcomes with no ...
John Michael Bryant, Max Shotbolt, Emmanuel Stimphil, Victoria Andre, Elric Zhang, Veronica Estrella, Kazim Husain, Joseph Weygand, Doug Marchion, Alex Sebastian Lopez, Dominique Abrahams, Shawnus Chen, Mostafa Abdel‐Mottaleb, Skye Conlan, Ibrahim Oraiqat, Vaseem Khatri, Jose Alejandro Guevara, Shari Pilon‐Thomas, Gage Redler, Kujtim Latifi, Natarajan Raghunand, Kosj Yamoah, Sarah Hoffe, James Costello, Jessica M. Frakes, Ping Liang, Robert A. Gatenby, Mokenge Malafa, Sakhrat Khizroev   +28 more
wiley   +1 more source

Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

BMC Cancer, 2010
Background Biliary tract cancers have limitations in information about different location-related pathogenesis and clinico-pathological characteristics.
You Young, Kim Dong-Goo, Chung Eun-Seon, Lee Myung, Won Hye, Hong Tae, Lee In-Seok   +6 more
doaj   +1 more source

Hepatic progenitor cells from adult human livers for cell transplantation. [PDF]

, 2008
Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of hepatocytes and premature differentiated progenitor cells ...
Aurich, H., Brockhoff, G., Christ, B., Jauch, Karl-Walter, Kirchner, S., Kunz-Schughart, L.A., Lichtenauer, M., Schlitt, H.-J., Stock, P., Thasler, Wolfgang E., Weiss, T.S.   +10 more
core   +1 more source

Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry [PDF]

, 2023
Kristina Zalevskaja, Jukka–Pekka Mecklin, Toni T. Seppälä   +2 more
openalex   +1 more source

Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial

The Lancet, 2023
R. Kelley, M. Ueno, C. Yoo, Richard S. Finn, J. Furuse, Z. Ren, T. Yau, H. Klümpen, Stephen L. Chan, M. Ozaka, C. Verslype, M. Bouattour, Joon-Oh Park, O. Barajas, U. Pelzer, J. Valle, Li Yu, U. Malhotra, A. Siegel, J. Edeline, A. Vogel, M. Akce, Inmaculada Ales Diaz, G. Alves, Sumitra Anand, Ç. Arslan, J. Asselah, E. Assenat, F. Aubin, L. Bai, Y. Bai, Susan Bates, S. Begbie, I. Ben-Aharon, Nina Beri, M. Berres, J. Blanc, I. Borbath, R. Bordonaro, G. Brandi, Adam H. Burgoyne, Kritiya Butthongkomvong, M. Camandaroba, Ke Cao, M. Carballido, Stephan Lam Chan, Jen‐Shi Chen, Ming-Huang Chen, Xiaoming Chen, A. Cheng, T. Chiu, Hye Jin Choi, H. Chon, J. Collignon, A. C. Gracián, Sarah Davis, Ricardo Saraiva de Carvalho, D. J. Groot, A. Demols, J. Vos, M. Diab, J. Easaw, M. Eatock, Rawad Elias, F. Eskens, A. Falcone, P. Fernández, Richard S. Finn, F. Franke, M. Furukawa, O. Gbolahan, K. Geboes, Keri-Lee Geneser, Zhimin Geng, R. Geva, R. Gillmore, T. Goetze, H. Gou, J. Grasselli, S. Gu, M. Gumus, N. H. Mohammad, C. Hao, H. Harputluoglu, H. Hatoum, V. Heinemann, W.K. Ho, Chiun Hsu, A. Hubert, J. Hwang, M. Inanc, S. Iseas, Vaishnavi Jeyasingam, P. Fonseca, W. Joubert, J. Juengsamarn, D. Kaen, Masashi Kanai, Stefan Kasper-Virchow, G. Kazemi, F. Kelleher, R. Kelley, Jin Won Kim, Jong Gwang Kim, A. Abrahao, H. Klumpen, M. Kochenderfer, F. Kose, Ho-Ching Lam, Choong-kun Lee, Hyun Woo Lee, Margaret Lee, M. Lee, W. Lee, S. Sourd, Dongliang Li, Wei Li, Houjie Liang, T. Liang, Chun Sen Lim, B. Lingerfelt, Charles A. Lopez, J. Low, T. M. Mercade, D. Malka, Y. Mao, G. Masi, S. McCune, R. McDermott, E. Mcwhirter, G. Mendez, M. Milella, Nobumasa Mizuno, T. Mizutani, C. Moniz, Luisa Morales, A. J. M. Martín, B. Nervi, N. Ngamphaiboon, S. Oh, B. Oksuzoglu, D. Outlaw, M. Ozguroglu, O. Ozyılkan, C. Painemal, Yueyin Pan, Chuang Peng, C. Pétorin, D. Pezet, D. Power, S. Qin, A. Roohullah, Hyewon Ryu, P. Salman, Mitsuhito Sasaki, R. Sasidharan, T. Satoh, K. Schulze, M. Scott-Brown, Rubén Segovia, Thomas Seufferlein, Salvatore Siena, I. Sinapi, C. Smolenschi, T. Song, A. Sookprasert, N. Soparattanapaisarn, N. Starling, S. Stein, S. Stemmer, Haichuan Su, R. Sugimoto, T. Suksombooncharoen, V. Tam, Ai Lian Tan, C. Tan, S. Tanasanvimon, G. Tonini, G. Tortora, A. Tsuji, Rodrigo Uribe, M. Venerito, H. Mata, A. Victorino, J. Wade, D. Waldschmidt, Lulu Wang, Wan Zamaniah Wan Isahk, Harpeet Wasan, R. Weschenfelder, Chun-yin Louisa Wong, Y. F. Wong, Ş. Yalçın, P. Weber, Xuezhong Yang, H. Yasui, O. Yazıcı, C. Yen, J. Ying, Wenchang Yu, Haitao Zhao   +200 more
semanticscholar   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source