Results 181 to 190 of about 193,970 (395)

CDK10 functions as a tumor suppressor gene and regulates survivability of biliary tract cancer cells

, 2011
Jianhua Yu, Xiangyu Zhong, Weiguang Zhang, Zhidong Wang, Qin Dong, Sheng Tai, Hui Li, Yunfu Cui   +7 more
openalex   +2 more sources

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

Targeting mTOR signaling for the treatment of intrahepatic cholangiocarcinoma with TSC1/ARID1A mutations: a case report with an unexpected response

Therapeutic Advances in Medical Oncology
Biliary tract cancer incidence is increasing and the prognostic remains dismal. The development of personalized medicine is a pivotal issue in proposing therapeutic options for biliary tract cancer patients.
Clémentine Daugan, Romain Boidot, François Ghiringhelli, Christophe Borg, Angélique Vienot   +4 more
doaj   +1 more source

COMPARISON OF ULTRASOUND WITH ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY AND SURGERY IN THE DETECTION OF SITE AND CAUSE BILE DUCTS DILATATION [PDF]

background and Objectives: Ultrasound (US) is the initial imaging test used in the evaluation of patients with biliary tract disease. Our retrospective study was designed to evaluate the capacity of ultrasound to determine the cause and site of bile ...
تبرائی, یاسر, رفاهی, سهیلا, مصباحی, سپیده, پورعیسی, مسعود   +3 more
core  

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Protein Induced by Vitamin K Absence or Antagonist‐II: Significantly Elevated in Obstructive Jaundice and Sepsis Patients Without Hepatocellular Carcinoma

Journal of Clinical Laboratory Analysis, EarlyView.
The PIVKA‐II produced by HCC may differ from that produced by obstructive jaundice and sepsis. Given that serum PIVKA‐II levels are abnormally elevated in patients with obstructive jaundice and sepsis, the results should be interpreted with caution in patients with hepatocellular carcinoma combined with these diseases. ABSTRACT Background PIVKA‐II is a
Ke Zhang, Xiarui Ye, Xianran Fu
wiley   +1 more source

Global, regional, and national quality of care of gallbladder and biliary tract cancer: a systematic analysis for the global burden of disease study 1990–2017 [PDF]

, 2021
Javad Khanali, Mohammad‐Reza Malekpour, Mohammadreza Azangou‐Khyavy, Sahar Saeedi Moghaddam, Negar Rezaei, Ali‐Asghar Kolahi, Mohsen Abbasi‐Kangevari, Esmaeil Mohammadi, Nazila Rezaei, Moein Yoosefi, Mohammad Keykhaei, Yosef Farzi, Fateme Gorgani, Bagher Larijani, Farshad Farzadfar   +14 more
openalex   +1 more source

Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.

The Lancet Oncology, 2019
J. Primrose, R. Fox, D. Palmer, H. Malik, R. Prasad, D. Mirza, A. Anthony, P. Corrie, S. Falk, M. Finch-Jones, H. Wasan, P. Ross, L. Wall, J. Wadsley, J. Evans, D. Stocken, R. Praseedom, Yuk Ting Ma, B. Davidson, J. Neoptolemos, T. Iveson, J. Raftery, Shihua Zhu, D. Cunningham, O. Garden, C. Stubbs, J. Valle, J. Bridgewater   +27 more
semanticscholar   +1 more source

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt, Kirsteen M. Donaldson, Jeevan R. Kunta, Joseph M. Custodio   +3 more
wiley   +1 more source

Differential Diagnosis of Malignant Biliary Tract Cancer from Benign Tissues using Apparent Diffusion Coefficient Measurements with Diffusion Weighted Imaging in Asians [PDF]

, 2015
Xuya Zhao, Shi Zhou, Da‐Zhi Wang, Wei He, Jun‐Xiang Li, Shuai Zhang   +5 more
openalex   +1 more source