Results 21 to 30 of about 193,970 (395)

Durvalumab: A Review in Advanced Biliary Tract Cancer

Targeted oncology, 2023
Biliary tract cancers are a diverse group of cancers that develop in the bile ducts or the gallbladder. Patients with these cancers typically have poor survival.
Simon Fung, Yahiya Y. Syed
semanticscholar   +1 more source

Case report: A de novo ERBB3 mutation develops in a gallbladder cancer patient carrying BRCA1 mutation after effective treatment with olaparib

Frontiers in Oncology, 2023
BackgroundGallbladder cancer (GBC) is highly lethal and resistant to most chemotherapeutic drugs. GBC was reported to carry multiple genetic mutations such as TP53, K-RAS, and ERBB2/3.
Jing-Xiao Yang, Zi-Yao Jia, Fa-Tao Liu, Wen-Guang Wu, Xue-Chuan Li, Xue-Chuan Li, Xue-Chuan Li, Lu Zou, Lu Zou, Lu Zou, Huai-Feng Li, Huai-Feng Li, Huai-Feng Li, Fei Zhang, Fei Zhang, Fei Zhang, Run-Fa Bao, Run-Fa Bao, Run-Fa Bao, Shu-You Peng, Wan Yee Lau, Yun Liu, Mao-Lan Li, Ying-Bin Liu, Ying-Bin Liu, Ying-Bin Liu   +25 more
doaj   +1 more source

Precision Oncology Targets in Biliary Tract Cancer

Cancers, 2023
Simple Summary Biliary tract cancer is rare in the US but remains a highly lethal cancer. While the standard of care in the first-line, metastatic setting is well-established, no second-line regimen has been clearly defined as the gold standard.
N. Farha, D. Dima, F. Ullah, Suneel D. Kamath   +3 more
semanticscholar   +1 more source

Exosomal MicroRNA signature acts as an efficient biomarker for non-invasive diagnosis of gallbladder carcinoma

iScience, 2022
Summary: Through a three-step study that relies on biomarker discovery, training, and validation, we identified a set of five exosomal microRNAs (miRNAs) that can be used to evaluate the risk of gallbladder carcinoma (GBC), including miR-552-3p, miR-581,
Pinghua Yang, Fengliang Song, Xinwei Yang, Xingzhou Yan, Xinyu Huang, Zhengjun Qiu, Zhijian Wen, Chi Liang, Xianglei Xin, Zhengqin Lei, Kecheng Zhang, Jue Yang, Hu Liu, Hongcheng Wang, Shijun Xiang, Liang Li, Baohua Zhang, Hongyang Wang   +17 more
doaj   +1 more source

Promising Genomic Testing for Biliary Tract Cancer Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration/Biopsy Specimens

Diagnostics, 2022
The undesired prognosis of biliary tract cancer is mainly attributed to the difficult detection of cancer lesions, including intraepithelial neoplasia and no standard examination for screening.
Masaki Kuwatani, Kazumichi Kawakubo, Naoya Sakamoto   +2 more
doaj   +1 more source

The global, regional, and national burden of gallbladder and biliary tract cancer and its attributable risk factors in 195 countries and territories, 1990 to 2017: A systematic analysis for the Global Burden of Disease Study 2017

Cancer, 2021
The global burden of gallbladder and biliary tract cancer (GBTC) is increasing. A comprehensive evaluation of the burden is crucial to improve strategies for GBTC prevention and treatment.
Guoqing Ouyang, Qiang Liu, Yongrong Wu, Zhen Liu, Wuchang Lu, Shuai Li, Guangdong Pan, Xiang Chen   +7 more
semanticscholar   +1 more source

N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes

iScience, 2023
Summary: CircRNAs play multiple roles in a variety of cellular processes. We found that Circ-CDYL is highly enriched in early HCC plasma exosomes. Moreover, EpCAM+ HCC cells and exosomes had significant Circ-CDYL levels.
Yanping Wei, Jingbo Fu, Hailing Zhang, Yan Ling, Xuewu Tang, Shuowu Liu, Miao Yu, Fuyan Liu, Guokun Zhuang, Haihua Qian, Kecheng Zhang, Pinhua Yang, Xinwei Yang, Qi Yang, Shennian Ge, Baohua Zhang, Yexiong Tan, Liang Li, Hongyang Wang   +18 more
doaj   +1 more source

PD-L1, TMB, MSI, and Other Predictors of Response to Immune Checkpoint Inhibitors in Biliary Tract Cancer

Cancers, 2021
Simple Summary Over the last decade, immune checkpoint inhibitors (ICIs) targeting programmed death 1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte antigen 4 (CTLA-4) have dramatically changed the therapeutic algorithm of several ...
A. Rizzo, A. Ricci, G. Brandi
semanticscholar   +1 more source

Interplay between the Human Microbiome and Biliary Tract Cancer: Implications for Pathogenesis and Therapy

Microorganisms, 2023
Biliary tract cancer, encompassing intrahepatic and extrahepatic cholangiocarcinoma as well as gallbladder carcinoma, stands as a prevalent malignancy characterized by escalating incidence rates and unfavorable prognoses.
Cheng Ye, Chunlu Dong, Yanyan Lin, Huaqing Shi, Wence Zhou   +4 more
doaj   +1 more source

Updated management of malignant biliary tract tumors: an illustrative review [PDF]

, 2016
The management of malignant biliary tumors (MBTs) is complex and requires a multidisciplinary approach. Guidelines and methods of staging for biliary tumors have recently been released by main international societies, altering the clinical and radiologic
Cannavale, Alessandro, Catalano, Carlo, Fanelli, Fabrizio, Fiocca, Fausto, Gazzetti, Marianna, Maher, Ben, Santoni, Mariangela   +6 more
core   +1 more source