Results 161 to 170 of about 298,077 (320)

Negative impact of corticosteroid use on outcome in patients with advanced BTCs treated with cisplatin, gemcitabine, and durvalumab: A large real‐life worldwide population

open access: yesInternational Journal of Cancer, EarlyView.
What's new? In recent years, the possible prognostic impact of concomitant medications in patients with cancer treated with immunotherapy combinations has generated increasing interest. This real‐world analysis evaluated the impact of concomitant medications on survival outcomes in patients with advanced biliary tract cancer treated with cisplatin ...
Federica Lo Prinzi   +71 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

open access: yesiMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu   +8 more
wiley   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

open access: yesiMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang   +12 more
wiley   +1 more source

Role of Adjuvant Chemotherapy in Distal Cholangiocarcinoma

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Recent studies addressing the role of adjuvant chemotherapy (AC) in cholangiocarcinoma (CCA) have been published; however, there are challenges in generalizing the findings due to different prognostic characteristics depending on tumor location and resectability.
Yoon Soo Chae   +9 more
wiley   +1 more source

Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background/Purpose Current guidelines do not provide specific recommendations regarding the timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute cholangitis (AC) concurrent with acute gallstone pancreatitis (AGP). This study evaluated the impact of ERCP timing on clinical outcomes.
Mustafa Comoglu   +6 more
wiley   +1 more source

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