Results 191 to 200 of about 282,772 (364)

SLCO1B1 Functional Variants, Bilirubin, Statin‐Induced Myotoxicity, and Recent Sub‐Saharan African Ancestry: A Precision Medicine Health Equity Study

Clinical Pharmacology &Therapeutics, EarlyView.
Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and are thus missing from guidelines.
Tanushree Haldar, Mark Kvale, Jia Yang, Michael P. Douglas, Willow Coyote‐Maetas, Linda Kachuri, John S. Witte, Carlos Iribarren, Marisa W. Medina, Ronald M. Krauss, Sook Wah Yee, Akinyemi Oni‐Orisan   +11 more
wiley   +1 more source

Binding of bilirubin to human serum albumin — determination of the dissociation constants [PDF]

, 1969
Jan Jacobsen
openalex   +1 more source

Optimizing Brentuximab Vedotin Dosing in Pediatric Patients with Advanced Hodgkin Lymphoma: A Population Pharmacokinetic and Exposure‐Response Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric patients with advanced‐stage newly diagnosed Hodgkin lymphoma (HL) were treated with brentuximab vedotin (BV) combined with adriamycin, vinblastine, and dacarbazine (A + AVD). Weight‐based BV dosing is employed in adult patients, while both body weight‐ and body surface area (BSA)‐based dosing are used in pediatric patients.
Xiaofei Zhou, Diane R. Mould, Lia Gore, Xiang Bai, Neeraj Gupta   +4 more
wiley   +1 more source

Night‐Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Concept of methylprednisolone chronotherapy to prevent acute rejections. While endogenous cortisol secretion rises in the early morning, the number of lymphocytes in the blood is higher at night, thus exhibiting an antiphase pattern to cortisol secretion. Therefore, compared with the daytime, the infiltration of lymphocytes into immune‐reactive tissues
Kentaro Ushijima, Yukihiro Sanada, Shinya Otomo, Keiko Ogaki, Taiichi Wakiya, Noriki Okada, Yuta Hirata, Yasuharu Onishi, Yasunaru Sakuma, Yukiyo Wada, Akio Fujimura, Koichi Mizuta   +11 more
wiley   +1 more source

THE FORMATION OF BILIRUBIN FROM HEMOGLOBIN IN VIVO* [PDF]

, 1962
J. Donald Ostrow, James H. Jandi, Rudi Schmid   +2 more
openalex   +1 more source

Confirmation of Fixed Quarterly Riliprubart Regimen in Patients with Cold Agglutinin Disease Using Population PK/PD and Exposure‐Response Analyses

Clinical Pharmacology &Therapeutics, EarlyView.
Riliprubart is a second‐generation, humanized immunoglobulin G4 that inhibits only the activated form of the C1s component of the proximal classical complement pathway. The clinical studies of riliprubart conducted thus far for the treatment of cold agglutinin disease (CAD), a rare autoimmune disease, include a Phase 1 first‐in‐human study in healthy ...
Timothy Chow, Marek Wardecki, Michael Storek, Nancy Wong   +3 more
wiley   +1 more source

BILIRUBIN AND UROBILINS IN GERMFREE, EX-GERMFREE, AND CONVENTIONAL RATS [PDF]

, 1960
Bengt E. Gustafsson, Lisa Swenander Lanke   +1 more
openalex   +1 more source

Role for inflammatory markers in predicting right ventricular failure in mechanical assist device recipients

ESC Heart Failure, EarlyView.
Abstract Right ventricular failure (RVF) is a common complication following left ventricular assist device (LVAD) implantation and increases patient morbidity and mortality. Due to the complex and limited understanding of RVF pathophysiology, efforts to prognosticate RVF after LVAD have been challenging.
Abdul‐Fatawu Osman, Shane S. Scott, Ebubechukwu O. Ezeh, Evans Osuji, Israel O. Ailemen, Mohamed H. Derbala, Salil Kumar, Asvin M. Ganapathi, Daniel B. Sims, Ashrith Guha, Bryan A. Whitson, Sakima A. Smith   +11 more
wiley   +1 more source

A New Diazo Method for the Determination of Bilirubin [PDF]

, 1962
R N Rand, Alfred di Pasqua
openalex   +1 more source

Bilirubin in the Liver–Gut Signaling Axis

Trends in endocrinology and metabolism, 2018
Abdul-rizaq Hamoud, L. Weaver, D. Stec, T. Hinds   +3 more
semanticscholar   +1 more source