Results 61 to 70 of about 210,308 (271)
Analysis and Discussion on the Design of Green Super High-rise Civil Buildings in Huangshan [PDF]
E3S Web of Conferences, 2019 With the accelerating urbanization process and the development of the construction industry, the role of green building design in architectural design is constantly reflected.
Jun Liu +4 more
doaj +1 more source
Applied Sciences, 2023 Digital twin technology can be used for disaster safety management of underground utility tunnels, which are social infrastructures. To verify its efficiency in an underground utility tunnel, it must be implemented and monitored in the real world ...
Sangmi Park +3 more
doaj +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
CellsNeutrophil extracellular traps (NETs) have received significant attention in recent years for their role in both the immune response and the vascular damage associated with inflammation.
Christopher Sennett, Giordano Pula
doaj +1 more source
Effects of the Interactions Between LPS and BIM on Workflow in Two Building Design Projects [PDF]
, 2014 Variability in design workflow causes delays and undermines the performance of building projects. As lean processes, the Last Planner System (LPS) and Building Information Modeling (BIM) can improve workflow in building projects through features that ...
Khan, Sheriz, Tzortzopoulos, Patricia
core
Design for safety: theoretical framework of the safety aspect of BIM system to determine the safety index [PDF]
, 2016 Despite the safety improvement drive that has been implemented in the construction industry in Singapore for many years, the industry continues to report the highest number of workplace fatalities, compared to other industries.
Kim, Hanjoon +3 more
core +3 more sources
Racism and racial disparities in firearm violence: A scoping review
American Journal of Community Psychology, EarlyView.Abstract Firearm violence (i.e., interpersonal, police firearm violence) disproportionately affects racially minoritized communities. Researchers recently shifted their focus from race to racism to better understand the factors that contribute to racial disparities in firearm violence.
Daniel B. Lee +8 more
wiley +1 more source
Hyperactivity and Pro-inflammatory Functions of Platelets in Diabetes
Frontiers in Bioscience-LandmarkCardiovascular complications claim the lives of up to 70% of patients with diabetes mellitus (DM). The mechanisms increasing cardiovascular risk in DM remain to be fully understood and successfully addressed.
Jordan Greaves, Giordano Pula
doaj +1 more source