Results 101 to 110 of about 137,267 (309)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang   +12 more
wiley   +1 more source

Soil Physics‐Informed Neural Networks to Estimate Bimodal Soil Hydraulic Properties

open access: yesWater Resources Research
Pedotransfer functions (PTFs) are widely used to estimate soil hydraulic properties (SHPs) from easily measurable soil properties. However, most existing PTFs are based on unimodal hydraulic models, which fail to capture the bimodal behavior of hydraulic
Jieliang Zhou   +6 more
doaj   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

open access: yesAdvanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis   +32 more
wiley   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan   +8 more
wiley   +1 more source

Experiment 5: Medium Bimodal and Wide Bimodal blocks, mean bias and nonparametrically inferred priors.

open access: yes, 2012
Very top: Experimental distributions for Medium Bimodal (dark purple, left) and Wide Bimodal (light purple, right) blocks. Top: Mean response bias across subjects (mean s.e.m.
Sethu Vijayakumar (118020)   +2 more
core   +1 more source

A facile synthesis of bimodal mesoporous silica and its replication for bimodal mesoporous carbon

open access: yes, 2019
Bimodal mesoporous silica material composed of 30similar to40 nm sized nanoparticles with 3.5 nm sized three-dimensionally interconnected mesopores was synthesized under neutral conditions using sodium silicate as a silica source.
Kim, J, Hyeon, T, Lee, J
core   +2 more sources

Foro con experto. Aplicación de las Nuevas Tecnologías de la Información y Comunicación en la formación farmacéutica / Forum with expert. Application of the New Technologies in pharmaceutical education

open access: yesActualidades Investigativas en Educación, 2008
Se presenta la primera experiencia de la Facultad de Farmacia de la Universidad de Costa Rica en la temática de las TIC`s. El proyecto Foro con experto tiene como finalidad poner en contacto al estudiantado avanzado de la carrera de Licenciatura en ...
Beatriz Badilla Baltodano
doaj   +1 more source

Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities

open access: yesAdvanced Science, EarlyView.
This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina   +6 more
wiley   +1 more source

Neoproterozoic bimodal magmatism in the Cathaysia Block of South China and its tectonic significance

open access: yes, 2005
SHRIMP U–Pb zircon age, geochemical and Sm–Nd isotopic results are reported for the Mamianshan volcanic rocks in the Cathaysia Block of southeastern South China.
Li, Zheng-Xiang   +5 more
core   +1 more source

Multi-frequency tapping-mode atomic force microscopy beyond three eigenmodes in ambient air

open access: yesBeilstein Journal of Nanotechnology, 2014
We present an exploratory study of multimodal tapping-mode atomic force microscopy driving more than three cantilever eigenmodes. We present tetramodal (4-eigenmode) imaging experiments conducted on a thin polytetrafluoroethylene (PTFE) film and ...
Santiago D. Solares   +2 more
doaj   +1 more source

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