Results 51 to 60 of about 84,276 (299)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Bimodal distribution of nested PCR-positive probabilities.

, 2018
The 21 OR genes tested in this study are binned according to the probability of observing a PCR product at the 400-cell input level across 22 OP6 cultures in two divergent lineages (see Fig 3).
J. C. Noble (5793989), Robert P. Lane (5793995), Diane Meredith (5793992)   +2 more
core   +1 more source

Generalized Centered Binomial Distribution for Bimodal Lattice Signatures

IEEE Access
In CRYPTO 2013, Ducas et al. introduced a bimodal discrete Gaussian distribution into the Fiat-Shamir with abort paradigm, proposing a signature scheme called BLISS, which significantly improved rejection sampling efficiency and reduced the number of ...
Seungwoo Lee, Joo Woo, Jonghyun Kim, Jong Hwan Park   +3 more
doaj   +1 more source

Unimodal head-width distribution of the European eel (Anguilla anguilla L.) from the Zeeschelde does not support disruptive selection [PDF]

PeerJ, 2018
Since the early 20th century, European eels (Anguilla anguilla L.) have been dichotomously classified into ‘narrow’ and ‘broad’ heads. These morphs are mainly considered the result of a differential food choice, with narrow heads feeding primarily on ...
Pieterjan Verhelst, Jens De Meyer, Jan Reubens, Johan Coeck, Peter Goethals, Tom Moens, Ans Mouton   +6 more
doaj   +2 more sources

Modelling Bimodal Data Using a Multivariate Triangular-Linked Distribution

Mathematics, 2022
Bimodal distributions have rarely been studied although they appear frequently in datasets. We develop a novel bimodal distribution based on the triangular distribution and then expand it to the multivariate case using a Gaussian copula. To determine the
Daan de Waal, Tristan Harris, Alta de Waal, Jocelyn Mazarura   +3 more
doaj   +1 more source

An Asymmetric Bimodal Distribution with Application to Quantile Regression [PDF]

Symmetry, 2019
In this article, we study an extension of the sinh Cauchy model in order to obtain asymmetric bimodality. The behavior of the distribution may be either unimodal or bimodal. We calculate its cumulative distribution function and use it to carry out quantile regression. We calculate the maximum likelihood estimators and carry out a simulation study.
Yolanda M. Gómez, Emilio Gómez-Déniz, Osvaldo Venegas, Diego I. Gallardo, Héctor W. Gómez   +4 more
openaire   +2 more sources

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Some Extensions of the Asymmetric Exponentiated Bimodal Normal Model for Modeling Data with Positive Support

Mathematics, 2023
It is common in many fields of knowledge to assume that the data under study have a normal distribution, which often generates mistakes in the results, since this assumption does not always coincide with the characteristics of the observations under ...
Roger Tovar-Falón, Guillermo Martínez-Flórez, Isaías Ceña-Tapia   +2 more
doaj   +1 more source

On the Bimodal Distributions of Horizontal Branches [PDF]

Symposium - International Astronomical Union, 1988
New synthetic horizontal branch (HB) models are presented for some globular clusters known to have bimodal HB distributions. These models are based on new Yale HB evolutionary tracks for Y=0.25 and the core masses appropriate for the compositions. The distribution of stellar masses along the HB is given by a slightly modified version of Rood's (1973 ...
Young-Wook Lee, Pierre Demarque, Robert Zinn   +2 more
openaire   +1 more source

Solid‐State Diffusion and Intermetallic Phase Formation in Roll‐Bonded Mg–Zn Composites With Kirigami‐Patterned Inlay

Advanced Engineering Materials, EarlyView.
Mg–Zn composites with a thickness of 0.21 mm were fabricated using roll bonding of a kirigami‐patterned Mg alloy inlay within a Zn matrix. Thermal activation following this process led to the formation of tailored intermetallic structures, which provided the composite with enhanced flexural strength.
Yaroslav Frolov, Oleksandr Bobukh, Christian Klose, Florian Nürnberger, Hans Jürgen Maier   +4 more
wiley   +1 more source