Results 21 to 30 of about 2,290 (262)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Stellar and circumstellar properties of visual binaries in the Orion Nebula Cluster [PDF]

, 2013
Context. Our general understanding of multiple star and planet formation is primarily based on observations of young multiple systems in low density regions like Tau-Aur and Oph.
S. Correia, B. Reipurth, Q. M. Konopacky, Ratzka, Th, Köhler, R, Duchêne, G, Reipurth, B, Daemgen, S, Konopacky, QM, Th. Ratzka, Correia, S, Petr-Gotzens, MG, G. Duchêne, H. Zinnecker, Ghez, AM, S. Daemgen, M. G. Petr-Gotzens, A. M. Ghez, Zinnecker, H, C. Aspin, Aspin, C, R. Köhler   +21 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

VIBES: Visual Binary Exoplanet survey with SPHERE

, 2020
Context. Recent surveys indicate that planets in binary systems are more abundant than previously thought, which is in agreement with theoretical work on disc dynamics and planet formation in binaries.
C. Fontanive, R. Jayawardhana, Kuhn, J., Reggiani, M., Quanz, S.P., S. P. Quanz, J. Kühn, Daemgen, S., M. Meyer, Engler, N., N. Engler, Meyer, M., Hagelberg, J., S. Daemgen, Fontanive, C., M. Reggiani, V. Kostov, Quanz, S. P., J. Hagelberg, Jayawardhana, R., Kostov, V.   +20 more
core   +1 more source

Signature visualization of software binaries

Proceedings of the 4th ACM symposium on Software visualization, 2008
In this paper we present work on the visualization of software binaries. In particular, we utilize ROSE, an open source compiler infrastructure, to pre-process software binaries, and we apply a landscape metaphor to visualize the signature of each binary (malware).
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Spectroscopic characterization of a sample of southern visual binaries

, 2006
Aims.We present the spectroscopic characterization of 56 pairs of visual binaries with similar components, based on high resolution spectra acquired with FEROS at ESO La Silla.
S. Desidera, S. Lucatello, R. G. Gratton, T. H. Dall, R. U. Claudi   +4 more
core   +1 more source

Speckle observations with PISCO in Calern (France): I. Astrometric measurements of visual binaries in 2015–2016 [PDF]

, 2019
International audienceWe present relative astrometric measurements of visual binaries, made in 2015-2016 with the speckle camera PISCO at the 1-m Epsilon telescope of the C2PU facility (Observatoire de la Côte d'Azur, Calern site).
Luigi Pansecchi, David Vernet, Vernet, David, Robert W. Argyle, Jean‐Pierre Rivet, Suarez, Olga, Argyle, Robert, W., Pansecchi, Luigi, Abe, Lyu, Argyle, Robert W., Eric Aristidi, Lyu Abe, Rivet, Jean-Pierre, Argyle, Robert,, Bendjoya, Philippe, Ling, Josefina F., Alessio Zanutta, Zanutta, Alessio, Aristidi, Eric, Josefina F. Ling, Rivet, Jean‐pierre, Marco Scardia, Jean‐Louis Prieur, Philippe Bendjoya, Ling, Josefina, Cécile Dimur, Dimur, Cécile, Prieur, Jean-Louis, Olga Suárez, Scardia, Marco   +29 more
core   +3 more sources

Orbits of 15 visual binaries.

The Astrophysical Journal Supplement Series, 1978
On a determine avec des observations recentes les elements orbitaux et les masses des paires ADS 1709, 2173, 3064, 3483, 3780, 7871, 8419, 10421, 11111, 12447, 12552, 12973, 15378, Φ 347 et Kpr 99.
openaire   +1 more source