Results 31 to 40 of about 2,290 (262)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Multiplicity among Visual Binaries [PDF]

International Astronomical Union Colloquium, 1977
AbstractA brief review of the history of multiple-star discovery is followed by a discussion of selection effects, discovery probability, and detection techniques. The incidence of multiplicity and the properties of multiples in various samples of binaries are investigated.
openaire   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Speckle observations with PISCO in Merate - V. Astrometric measurements of visual binaries in 2006 [PDF]

, 2008
International audienceWe present relative astrometric measurements of visual binaries made during the first semester of 2006, with the Pupil Interferometry Speckle camera and COronagraph at the 102-cm Zeiss telescope of the Brera Astronomical Observatory,
Basso, Stefano, Prieur, J.-L., M. Sala, Ghigo, Mauro, R. W. Argyle, L. Pansecchi, J.-L. Prieur, Pansecchi, Luigi, Koechlin, Laurent, M. Ghigo, Argyle, R. W., E. Aristidi, L. Koechlin, Aristidi, Eric, Sala, M., Basso, S., Koechlin, L., Ghigo, M., Pansecchi, L., Aristidi, E., M. Scardia, Scardia, M., Prieur, Jean-Louis, Scardia, Marco, Marco, Sala   +24 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Spatially resolved spectroscopy of close massive visual binaries with HST/STIS

, 2020
Context. The spectroscopic characterization of many O-type stars is hampered by a nearby companion. Aims. We want to obtain spatially resolved spectroscopy of close O-type visual binaries to derive their spectral types. Methods.
R. H. Barbá, J. Maíz Apellániz, Maíz Apellániz, Jesús, Barbá, R. H.   +3 more
core   +1 more source

Speckle observations with PISCO in Merate - II. Astrometric measurements of visual binaries in 2004 [PDF]

, 2006
International audienceWe present relative astrometric measurements of visual binaries taken during the second semester of 2004 with the Pupil Interferometry Speckle camera and Coronagraph (PISCO) at the 1-m Zeiss telescope of the Brera Astronomical ...
Koechlin, L., Ghigo, M., Pansecchi, L., Aristidi, E., Scardia, M., Prieur, J.-L., Sala, M., Argyle, R. W.   +7 more
core   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source