Results 31 to 40 of about 642,707 (262)

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy   +5 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

THE CONCEPT OF PERFORMING THE ADDITION OPERATION IN THE SYSTEM OF RESIDUAL CLASSES

open access: yesСучасні інформаційні системи, 2022
The subject of the article is the development of a method for implementing the arithmetic operation of adding the residuals of numbers, which are represented in the system of residual classes (RNS).
Victor Krasnobayev   +2 more
doaj   +1 more source

Binary Representation of Natural Numbers [PDF]

open access: yesFormalized Mathematics, 2018
Summary Binary representation of integers [5], [3] and arithmetic operations on them have already been introduced in Mizar Mathematical Library [8, 7, 6, 4]. However, these articles formalize the notion of integers as mapped into a certain length tuple of boolean values.
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Binary quantum random number generator based on value indefinite observables

open access: yesScientific Reports
All quantum random number generators based on measuring value indefinite observables are at least three-dimensional because the Kochen–Specker Theorem and the Located Kochen–Specker Theorem are false in dimension two.
Cristian S. Calude, Karl Svozil
doaj   +1 more source

Sloping Binary Numbers: A New Sequence Related to the Binary Numbers

open access: yes, 2005
If the list of binary numbers is read by upward-sloping diagonals, the resulting ``sloping binary numbers'' 0, 11, 110, 101, 100, 1111, 1010, ... (or 0, 3, 6, 5, 4, 15, 10, ...) have some surprising properties. We give formulae for the n-th term and the n-th missing term, and discuss a number of related sequences.
Applegate, David   +3 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

On the Number of Subword Reconstructions in the Binary Alphabet when Superimposed on one Character

open access: yesСовременные информационные технологии и IT-образование, 2020
The problem of obtaining accurate estimates of the number of reconstructions for words over a binary alphabet is considered. Subwords of different lengths from a given set are joined by the method of overlapping end characters.
Galina Zhukova   +2 more
doaj   +1 more source

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