Results 41 to 50 of about 62,654 (258)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
THE CONCEPT OF PERFORMING THE ADDITION OPERATION IN THE SYSTEM OF RESIDUAL CLASSES
Сучасні інформаційні системи, 2022 The subject of the article is the development of a method for implementing the arithmetic operation of adding the residuals of numbers, which are represented in the system of residual classes (RNS).
Victor Krasnobayev +2 more
doaj +1 more source
Combinatorial numbers in binary recurrences [PDF]
Periodica Mathematica Hungarica, 2009 Under the combinatorial numbers in the title are meant the Fibonacci (denoted by F), Lucas (L), Pell (P) or associated Pell (Q) numbers. Three main theorem of the paper contain effective finiteness results on the solubility of equation (1) \(p(x)=U_n\), \(n\geq2, x\in\mathbb Z\), where \(p(x)\) is one of the polynomials \(S_k(x)=\sum_{i=1}^{x-1}i^k\), \
openaire +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
RESEARCH ON NUMBER THEORY AND SMARANDACHE NOTIONS [PDF]
, 2010 This Book is devoted to the proceedings of the Sixth International Conference on Number Theory and Smarandache Notions held in Tianshui during April 24-25, 2010.
Wenpeng, Zhang
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Analysis of Binary Number Association Scheme Partially Balanced Designs [PDF]
, 1973 46 pages, 1 article*Analysis of Binary Number Association Scheme Partially Balanced Designs* (Paik, U. B.; Federer, W.
Paik, U. B. +4 more
core
Binary-trans, non-binary and gender-questioning adolescents’ experiences in UK schools
, 2023 A growing number of adolescents are using a number of different identities to describe their gender. Schools have been noted for their uninclusive environments and high levels of discrimination for LGBTQ + individuals, yet research has neglected the ...
Sophie Zadeh (18273901) +2 more
core
Binary quantum random number generator based on value indefinite observables
Scientific ReportsAll quantum random number generators based on measuring value indefinite observables are at least three-dimensional because the Kochen–Specker Theorem and the Located Kochen–Specker Theorem are false in dimension two.
Cristian S. Calude, Karl Svozil
doaj +1 more source