Results 41 to 50 of about 1,318,479 (292)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMEX evolution of scalar fields on curved backgrounds [PDF]

, 2009
Inspiral of binary black holes occurs over a time-scale of many orbits, far longer than the dynamical time-scale of the individual black holes. Explicit evolutions of a binary system therefore require excessively many time steps to capture interesting ...
Hesthaven, Jan S., Lau, Stephen R., Pfeiffer, Harald P.   +2 more
core   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Eco‐Friendly Extraction and Utilization of Agro Crop Wastes Based Natural Dye for Textile Dyeing

Energy Science & Engineering
The incorporation of waste plant residues into practical applications, particularly as a sustainable source of green dyes in textiles, is increasingly recommended by the global community.
Nimra Amin, Fazal‐ur‐ Rehman, Shahid Adeel, Muhammad Ibrahim, Rony Mia   +4 more
doaj   +1 more source

Approximate cost-efficient sequential designs for binary response models with application to switching measurements

, 2008
The efficiency of an experimental design is ultimately measured in terms of time and resources needed for the experiment. Optimal sequential (multi-stage) design is studied in the situation where each stage involves a fixed cost. The problem is motivated
Abdelbasit, Biedermann, Birge, Caldeira, Chaloner, Chaudhuri, Chaudhuri, Dixon, Dorta-Guerra, Dror, Ford, Gezmu, Hastie, Ivanova, Josephson, Juha Karvanen, Karvanen, Karvanen, Karvanen, Mathew, McCullagh, McLeish, Minkin, Pekola, Robbins, Sitter, Sitter, Sitter, Tekle, Woods, Wu   +30 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Modeling Transport Mode Decisions Using Hierarchical Binary Spatial Regression Models with Cluster Effects [PDF]

, 2004
This work is motivated by a mobility study conducted in the city of Munich, Germany. The variable of interest is a binary response, which indicates whether public transport has been utilized or not.
Czado, Claudia, Prokopenko, S.
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Bin-3-Way-PARAFAC-PLS: A 3-Way Partial Least Squares for Binary Response

Axioms
In various research domains, researchers frequently encounter multiple datasets pertaining to the same subjects, with one dataset providing explanatory variables for the others.
Elisa Frutos-Bernal, Laura Vicente-González, Ana Elizabeth Sipols   +2 more
doaj   +1 more source