Results 41 to 50 of about 449,237 (302)

Stroop interference and Reverse-Stroop interference measured by the response time of binary Yes/No decisions

Journal of Human Environmental Studies, 2023
This article proposes a binary Yes/No decision method to measure Stroop and Reverse-Stroop interferences. In the proposition, participants judge whether one given color name (or one given color patch) is consistent or inconsistent with the color (or the ...
Kazuho Fukuda, Kenta Toda
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Multi-stage Optional Unrelated Question RRT Model [PDF]

Journal of Statistical Theory and Applications (JSTA), 2016
Sihm et al. (2014) introduced modified optional unrelated question RRT model in both binary and quantitative response situations wherein the prevalence of the sensitive variable and the sensitivity level of the underlying sensitive question could be ...
Anu Chhabra, B.K. Dass, Samridhi Mehta
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Response-Based Sampling for Binary Choice Models With Sample Selection

Econometrics, 2018
Sample selection models attempt to correct for non-randomly selected data in a two-model hierarchy where, on the first level, a binary selection equation determines whether a particular observation will be available for the second level (outcome equation)
Maria Felice Arezzo, Giuseppina Guagnano   +1 more
doaj   +1 more source

Reconfigurable THz Metamaterial Filter Based on Binary Response for Information Processing System

Frontiers in Physics, 2021
Light-matter interactions between the metallic and dielectric layers along with the controlling of electromagnetic waves can create a way to develop micro-devices and moderate the functionalities for advanced applications.
Eistiak Ahamed, Ahmed Mahfuz Tamim, Mohammad Rashed Iqbal Faruque, Rasheduzzaman Sifat, Mohammad Tariqul Islam   +4 more
doaj   +1 more source

Graded and binary responses in stochastic gene expression [PDF]

Physical Biology, 2004
Recently, several theoretical and experimental studies have been undertaken to probe the effect of stochasticity on gene expression (GE). In experiments, the GE response to an inducing signal in a cell, measured by the amount of mRNAs/proteins synthesized, is found to be either graded or binary.
Karmakar, Rajesh, Bose, Indrani
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source