Results 51 to 60 of about 923,150 (240)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The evolution of a supermassive binary caused by an accretion disc

, 1998
The interaction of a massive binary and a non-self-gravitating circumbinary accretion disc is considered. The shape of the stationary twisted disc produced by the binary is calculated.
A. G. Polnarev, Artymowicz, Artymowicz, Artymowicz, Bahcall, Begelman, Demianski, Goldreich, Illarionov, Ivanov, Ivanov, J. C. B. Papaloizou, Jensen, Jensen, Kumar, Kumar, Kumar, Lehto, Lightman, Lin, Lin, Lin, Lyubarskii, P. B. Ivanov, Papaloizou, Papaloizou, Papaloizou, Peters, Petterson, Polnarev, Pringle, Quinlan, Quinlan, Rees, Scheuer, Shakura, Spitzer, Syer, Vokrouhlicky, Ward, Young   +40 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Efficient Solution-Processed Blue and Yellow Phosphorescent Organic Light-emitting Diodes Using Binary Blend Hosts

Medžiagotyra, 2022
The appropriate hosts of emitting layers (EMLs) play an important role in determining the overall performance of solution-processed phosphorescent organic light emitting diodes (PhOLEDs). We have investigated the effect of three species of host molecules,
Yuxin GUAN, Wenjing LIN, Qiannan WANG, Pengchao ZHOU, Bin WEI, Yingjie LIAO   +5 more
doaj   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

FEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu, Yumi Iwashita, Keisuke Tachibana, Itsuki Nishino, Yuki Niwa, Atsuko Uyeda, Kazuki Matsuo, Masahiro Nagahama, Masuo Kondoh   +8 more
wiley   +1 more source

Light Curve Solution of the Contact Binary AW UMa [PDF]

Journal of Astronomy and Space Sciences, 1997
A total of 1088 observations (272 in B,272 in V, 272 in R, and 272 in I) were made from January to February in 1995 at Chungbuk National University observatory(CbNUO). We constructed BVRI light curves with our data.
J. H. Jeong, Y. S. Lee, J. R. Yim
doaj  

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Efficient Merger of Binary Supermassive Black Holes in Merging Galaxies

, 2011
In spherical galaxies, binary supermassive black holes (SMBHs) have difficulty reaching sub-parsec separations due to depletion of stars on orbits that intersect the massive binary - the final-parsec problem.
Andreas Just, Berczik, Berczik, David Merritt, Dehnen, Escala, Fazeel Mahmood Khan, Ferrarese, Haehnelt, Jaffe, Komossa, Makino, Makino, Menou, Merritt, Merritt, Merritt, Milosavljević, Milosavljević, Perets, Peters, Roos, Sesana, van der Marel, Volonteri, Wyithe   +25 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A near horizon extreme binary black hole geometry

European Physical Journal C: Particles and Fields, 2019
A new solution of four-dimensional vacuum General Relativity is presented. It describes the near horizon region of the extreme (maximally spinning) binary black hole system with two identical extreme Kerr black holes held in equilibrium by a massless ...
Jacob Ciafre, Maria J. Rodriguez
doaj   +1 more source