Results 81 to 90 of about 210,765 (341)

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler, Aleksandra Maleska Maceski, Sofia Sandgren, Johanna Oechtering, Sabine Schaedelin, Lisa Hofer, Amar Zadic, Juan Francisco Vilchez Gomez, Lester Melie‐Garcia, Alessandro Cagol, Riccardo Galbusera, Sebastian Finkener, Patrice Lalive, Marjolaine Uginet, Stefanie Müller, Caroline Pot, Amandine Mathias, Renaud Du Pasquier, Robert Hoepner, Andrew Chan, Giulio Disanto, Chiara Zecca, Marcus D’Souza, Lars G. Hemkens, Tobias Derfuss, Özgür Yaldizli, Patrick Roth, Claudio Gobbi, David Brassat, Björn Tackenberg, Henrik Zetterberg, Tjalf Ziemssen, Heinz Wiendl, Klaus Berger, Marco Hermesdorf, Fredrik Piehl, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline A. J. Willemse, Pascal Benkert, Jens Kuhle, Swiss Multiple Sclerosis Cohort Study (SMSC)   +43 more
wiley   +1 more source

Characterization of Low-mass Companions to Kepler Objects of Interest Observed with APOGEE-N

The Astrophysical Journal Supplement Series, 2023
We report the characterization of 28 low-mass (0.02 M _⊙ ≤ M _2 ≤ 0.25 M _⊙ ) companions to Kepler objects of interest (KOIs), eight of which were previously designated confirmed planets.
Caleb I. Cañas, Chad F. Bender, Suvrath Mahadevan, Dmitry Bizyaev, Nathan De Lee, Scott W. Fleming, Fred Hearty, Steven R. Majewski, Christian Nitschelm, Donald P. Schneider, Javier Serna, Keivan G. Stassun, Guđmundur Stefánsson, Guy S. Stringfellow, John C. Wilson   +14 more
doaj   +1 more source

The importance of binary stars

Contributions of the Astronomical Observatory Skalnaté Pleso
Review paper to appear in the special issue of Contributions of the Astronomical Observatory Skalnate Pleso "Binary and Multiple Stars in the Era of Big Sky Surveys" (Kopal 2024)
H.M.J. Boffin, D. Jones
openaire   +2 more sources

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

Speckle Interferometry at SOAR Telescope in 2023

The Astronomical Journal
Results of the speckle-interferometry observations at the 4.1 m Southern Astrophysical Research Telescope obtained during 2023 are presented: 1913 measurements of 1533 resolved pairs or subsystems (median separation 0.″16) and nonresolutions of 552 ...
Andrei Tokovinin, Brian D. Mason, Rene A. Mendez, Edgardo Costa   +3 more
doaj   +1 more source

Pre‐Diagnostic Features of Multiple Sclerosis in a Diverse UK Cohort: A Nested Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Many patients with Multiple Sclerosis (MS) experience nonspecific symptoms prior to diagnosis. This period—the 'MS prodrome'—has been described in socio‐economically homogeneous cohorts to date. It remains unclear to what extent events prior to an MS diagnosis differ according to social determinants of health. Methods We conducted a
Pooja Tank, Benjamin M. Jacobs, Jonathan Bestwick, Ruth Dobson   +3 more
wiley   +1 more source

The BINSYN Program Package [PDF]

Journal of Astronomy and Space Sciences, 2012
The BINSYN program package, recently expanded to calculate synthetic spectra of cataclysmic variables, is being further extended to include synthetic photometry of ordinary binary stars in addition to binary stars with optically thick accretion disks ...
Albert P. Linnell
doaj   +1 more source

Wolf-Rayet stars in the Small Magellanic Cloud as testbed for massive star evolution

, 2018
The majority of Wolf-Rayet (WR) stars represent the stripped cores of evolved massive stars who lost most of their hydrogen envelope. In low metallicity environments, such as the Small Magellanic Cloud (SMC), stellar winds are weaker and binary ...
Langer, Norbert, Schootemeijer, Abel
core   +1 more source

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Mining Double-line Spectroscopic Candidates in the LAMOST Medium-resolution Spectroscopic Survey Using a Human–AI Hybrid Method

The Astrophysical Journal Supplement Series
We utilize a hybrid approach that integrates the traditional cross-correlation function (CCF) and machine learning to detect spectroscopic multiple star systems, specifically focusing on double-line spectroscopic binaries (SB2s).
Shan-shan Li, Chun-qian Li, Chang-hua Li, Dong-wei Fan, Yun-fei Xu, Lin-ying Mi, Chen-zhou Cui, Jian-rong Shi   +7 more
doaj   +1 more source