Results 71 to 80 of about 148,662 (310)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Unveiling the Potential of Diatomaceous Earth for the Synthesis of Sustainable Geopolymer Binders [PDF]

open access: yesMaterials Research
This study explored the use of natural diatomaceous earth (ND) and brewery waste diatomaceous earth (BWD) as precursors for the synthesis of geopolymeric binders, with a focus on optimizing the developed compositions and analyzing their physico ...
R. S. Magalhães   +3 more
doaj   +1 more source

Effects of additives in colloidal silica based inorganic-hybrid binder for mineral wool insulation boards

open access: yesJournal of Asian Ceramic Societies, 2020
In the mineral insulation board industry, it has been a challenge to replace the current organic binder to eco-friendly inorganic binder to enhance the fire-resistance, and reduce toxicity.
Hyunseok Ko, Hee-Seon Lee, Hyung Mi Lim
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

An Investigation of the Effect of Pyrolytic Liquid Obtained From Waste Tire on the Corrosion Behaviours of MgO-C Refractories

open access: yesHittite Journal of Science and Engineering, 2019
In this study, corrosion behaviours of MgO-C refractories by incorporating different binders as phenolic resin and pyrolytic liquid obtained by waste tire pyrolysis were investigated. Moreover, the effect of porosity on the corrosion resistance of those
Tuba Bahtli   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

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