Results 141 to 150 of about 8,384,443 (422)
Nucleic Acids Res., 2017 We present a major update of the HOCOMOCO collection that consists of patterns describing DNA binding specificities for human and mouse transcription factors.
I. Kulakovskiy +11 more
semanticscholar +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
The evolution of complex gene regulation by low specificity binding sites
, 2012 Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost ...
Plotkin, Joshua B. +1 more
core +1 more source
Dogon pronominal systems their nature and evolution
Studies in African Linguistics, 1994 The Dogon language family has received little attention in the linguistics literature to date. In this paper we examine the binding properties of the pronominal systems of three Dogon languages, Donno S:>, T:>r:> S:>, and Togo Ka.
Cristopher Culy, Kungarma Kodio
doaj +1 more source
Topological fingerprints reveal protein-ligand binding mechanism [PDF]
arXiv, 2017 Protein-ligand binding is a fundamental biological process that is paramount to many other biological processes, such as signal transduction, metabolic pathways, enzyme construction, cell secretion, gene expression, etc. Accurate prediction of protein-ligand binding affinities is vital to rational drug design and the understanding of protein-ligand ...
arxiv
Binding Affinity via Docking: Fact and Fiction
Molecules, 2018 In 1982, Kuntz et al. published an article with the title “A Geometric Approach to Macromolecule-Ligand Interactions”, where they described a method “to explore geometrically feasible alignment of ligands and receptors of known structure”.
Tatu Pantsar, A. Poso
semanticscholar +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Glycolytic enzymes - novel carbohydrate binding proteins for glycoprotein analysis [PDF]
, 2011 •The cloning, expression, purification and characterisation of recombinant prokaryotic glycolytic enzymes •The mutagenesis of prokaryotic glycolytic enzymes to generate novel recombinant carbohydrate binding proteins •The characterisation of the ...
Clarke, Paul A. +3 more
core
Beilstein Journal of Organic Chemistry, 2020 When faced with the investigation of the preferential binding of a series of ligands against a known target, the solution is not always evident from single structure analysis.
Christopher B. Barnett +2 more
doaj +1 more source
The lock and key model for Molecular Recognition. Is it time for a paradigm shift? [PDF]
arXiv, 2018 We review the standard lock and key (LK) model for binding small ligands to larger adsorbent molecule. We discuss three levels of the traditional LK model for binding. Within this model the binding constant or the Gibbs energy of the binding process is related to the total interaction energy between the ligand and the binding site of the adsorbent ...
arxiv