Results 201 to 210 of about 3,573,689 (297)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Structural Insights into the Interaction Between a Core-Fucosylated Foodborne Hexasaccharide (H₂N₂F₂) and Human Norovirus P Proteins. [PDF]

Viruses
Zhang Z, Wang Y, Xu J, Liu F, Li S, Cox JT, Xue L, Liu D.   +7 more
europepmc   +1 more source

Image 1_The distinct effects of metformin and imeglimin on high glucose-induced alterations in metabolic function and reactive oxygen species production in mouse Schwann cells are modulated by pemafibrate and/or fatty acid-binding proteins..tif

Hiroshi Ohguro (351560), Megumi Higashide (22106714), Nami Nishikiori (22106717), Toshifumi Ogawa (20527520), Masato Furuhashi (85555), Tatsuya Sato (317466), Megumi Watanabe (223693)   +6 more
openalex   +1 more source

Characterization of β-adrenoceptors in pig basilar artery from functional and radioligand binding studies

, 1992
Atsushi Miyamoto, Ken Ito, Akira Nishio
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Investigating operational stability and causes of cofactor release in fold type I amine transaminase. [PDF]

Protein Sci
Feng X, Chau W, Master ER.
europepmc   +1 more source

Binding of PKARIɑ from A549 cells to cCMP and cUMP using biotin-matrices.

Sabine Wolter (152222), Martin Neumann (276593), Theresa Koenig (22430846), Tina Hagedorn (22430849), Frank Schwede (103997), Andreas Pich (152212), Roland Seifert (104001)   +6 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Susceptibility of broad reactivity nanobodies to resistance mutations in the S2 domain of SARS-CoV-2 predicted by yeast display deep mutational scanning. [PDF]

Front Immunol
Ball CR, Ramage W, Mate R, Hufton SE.
europepmc   +1 more source

Binding affinity of pAPN with the S proteins of PEDV, TGEV, and SADS-CoV revealed by docking structure and SPR.

Da An (21627567), Yan Li (23143), Yi Pei (54574), Yong-Hao Ma (2869658), Fei Yao (43685), Yongzhi Feng (11861457), Yanke Shan (5978276), Fei Liu (21082)   +7 more
openalex   +1 more source