Results 291 to 300 of about 8,384,443 (422)

Terms of binding

, 2006
The present dissertation aimed at achieving two goals. First, it constitutes an attempt to widen the search for phenomena that bear relevance to the idea that binding has a syntactic residue and is not, therefore, an exclusively semantic matter. Second, it tried to provide the technical means to account for these phenomena.
openaire   +3 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer. [PDF]

Cancer Med
Hara T, Meng S, Arao Y, Saito Y, Inoue K, Rennie S, Ofusa K, Kitagawa T, Ishii H.   +8 more
europepmc   +1 more source

The Role of IGF-1 and Hormone Binding Proteins in Understanding Insulin-Associated Equine Laminitis [PDF]

, 1905
Sachith N Nanayakkara
openalex   +1 more source

Freedom to bind [PDF]

Nature Chemical Biology, 2019
openaire   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Revealing two distinct molecular binding modes in polyethyleneimine-DNA polyplexes using infrared spectroscopy.

Soft Matter
Mustafa R, Diorio D, Harper M, Punihaole D.   +3 more
europepmc   +1 more source

Structural and mechanistic profiling of Nurr1 modulation by vidofludimus enables structure-guided ligand design. [PDF]

Commun Chem
López-García Ú, Vietor J, Marschner JA, Heering J, Morozov V, Wein T, Merk D.   +6 more
europepmc   +1 more source

SPECIFIC INTRACELLULAR BINDING OF RUBIDIUM BY RAT DIAPHRAGM MUSCLE [PDF]

, 1959
P. Menozzi, David Norman, A Polleri, Gillian M. Schiralli Lester, Oscar Hechter   +4 more
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source