Results 311 to 320 of about 8,384,443 (422)

The YoaA-χ helicase modulates the dynamics of single-stranded DNA binding protein on DNA. [PDF]

Nat Commun
Weeks-Pollenz SJ, Petrides MJ, Padgett-Pagliai KA, Davis R, Harris KK, Bloom LB.   +5 more
europepmc   +1 more source

TOLUIDINE BLUE BINDING BY DEVELOPING MUSCLE TISSUE: ASSAY AND DATA ON THE MECHANISM INVOLVED

, 1950
Heinz Herrmann, J. S. Nicholas, Jean K. Boricious   +2 more
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Structural plasticity of the FOXO-DBD:p53-TAD interaction. [PDF]

Nat Commun
Kohoutova K, Srb P, Obsilova V, Veverka V, Obsil T.   +4 more
europepmc   +1 more source

A census of human RNA-binding proteins

Nature reviews genetics, 2014
S. Gerstberger, M. Hafner, T. Tuschl
semanticscholar   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Competitive binding of actin and SH3 domains at proline-rich regions of Las17/WASP regulates actin polymerisation. [PDF]

Commun Biol
Hancock LP, Palmer JS, Allwood EG, Smaczynska-de Rooij II, Hodder AJ, Rowe ML, Williamson MP, Ayscough KR.   +7 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Interaction networks of SIM-binding groove mutants reveal alternate modes of SUMO binding and profound impact on SUMO conjugation. [PDF]

Sci Adv
Claessens LA, Verlaan-de Vries M, Broekman N, Luijsterburg MS, Vertegaal ACO.   +4 more
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source