Results 61 to 70 of about 7,717,990 (282)

‘Non-specific’ binding. The problem, and a solution [PDF]

Biochemical Journal, 1985
The concept of ‘non-specific’ binding, as it relates to studies of the binding of hormones to their receptors, is reviewed. It is concluded that the most widely used operational definition, namely binding that is not displaceable by an excess of unlabelled ligand, is often inaccurate, resulting either in overestimation of the number of high-affinity ...
C M, Mendel, D B, Mendel
openaire   +2 more sources

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Hardt's surprising sloppy readings : a flat binding account [PDF]

, 2009
The paper presents an additional argument for a specific account of semantic binding: the flat-binding analysis. The argument is based on observations concerning sloppy interpretations in verb phrase ellipsis when the binder is not the subject of the ...
Sauerland, Uli
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Evolutionary origins of synchronization for integrating information in neurons

Frontiers in Cellular Neuroscience
The evolution of brain-expressed genes is notably slower than that of genes expressed in other tissues, a phenomenon likely due to high-level functional constraints.
Takashi Shibata, Takashi Shibata, Noriaki Hattori, Hisao Nishijo, Tsutomu Takahashi, Tsutomu Takahashi, Yuko Higuchi, Yuko Higuchi, Satoshi Kuroda, Kaoru Takakusaki   +9 more
doaj   +1 more source

A (Somewhat) New Solution to the Variable Binding Problem [PDF]

Neural Computation, 2008
To perform automatic, unconscious inference, the human brain must solve the binding problem by correctly grouping properties with objects. Temporal binding models like SHRUTI already suggest much of how this might be done in a connectionist and localist way by using temporal synchrony.
Leon Barrett, Jerome Feldman, Liam MacDermed   +2 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A Mechanistic Model of Perceptual Binding Predicts That Binding Mechanism Is Robust against Noise

Entropy
The concept of the brain’s own time and space is central to many models and theories that aim to explain how the brain generates consciousness. For example, the temporo-spatial theory of consciousness postulates that the brain implements its own inner ...
Pavel Kraikivski
doaj   +1 more source

MD-SVM: a novel SVM-based algorithm for the motif discovery of transcription factor binding sites

BMC Bioinformatics, 2019
Background Transcription factors (TFs) play important roles in the regulation of gene expression. They can activate or block transcription of downstream genes in a manner of binding to specific genomic sequences.
Jialu Hu, Jingru Wang, Jianan Lin, Tianwei Liu, Yuanke Zhong, Jie Liu, Yan Zheng, Yiqun Gao, Junhao He, Xuequn Shang   +9 more
doaj   +1 more source

A reinforcement learning approach for protein–ligand binding pose prediction

BMC Bioinformatics, 2022
Protein ligand docking is an indispensable tool for computational prediction of protein functions and screening drug candidates. Despite significant progress over the past two decades, it is still a challenging problem, characterized by the still limited
Chenran Wang, Yang Chen, Yuan Zhang, Keqiao Li, Menghan Lin, Feng Pan, Wei Wu, Jinfeng Zhang   +7 more
doaj   +1 more source