Results 281 to 290 of about 8,730,538 (402)

Revealing the location and dynamics of a concealed binding site in the dopamine transporter. [PDF]

Nat Commun
Zhu R, Sandtner W, Stockner T, Heilinger A, Holy M, Kudlacek O, Wildling L, Saha K, Fröhlich AS, Bindl M, Tziortzouda P, Haider A, Gobl J, Suh SH, Khan JA, Bicher J, Kastner N, Ebner A, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.   +22 more
europepmc   +1 more source

SpatConv Enables the Accurate Prediction of Protein Binding Sites by a Pretrained Protein Language Model and an Interpretable Bio-spatial Convolution

Mingming Guan, Jiyun Han, Shizhuo Zhang, Hongyu Zheng, Juntao Liu   +4 more
openalex   +1 more source

How does a drug molecule find its target binding site?

Journal of the American Chemical Society, 2011
Yibing Shan, Eric T. Kim, M. Eastwood, R. Dror, M. Seeliger, D. Shaw   +5 more
semanticscholar   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Engineering a Functional Histidine Brace Copper-Binding Site into a <i>De Novo</i>-Designed Protein Scaffold. [PDF]

JACS Au
La Gatta S, Leone L, Sgueglia G, Šimunić L, Liao YK, Vaněk O, Chino M, Nastri F, Chiesa M, Lombardi A.   +9 more
europepmc   +1 more source

Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors^,

, 2007
L.L. Lovelace, Lydia M. Gibson, Lebioda
openalex   +1 more source

Oligomycin frames a common drug-binding site in the ATP synthase

Proceedings of the National Academy of Sciences of the United States of America, 2012
J. Symerský, D. Osowski, D. Walters, D. Mueller   +3 more
semanticscholar   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

N-glycosylation at the receptor binding site drives differences in receptor binding specificity between influenza B virus lineages. [PDF]

J Virol
Page CK, Mubassir MHM, Chopra P, Gay LC, Geiger G, Ray SD, Shepard JD, Miller RJ, Perez D, Bahl J, Boons GJ, Tompkins SM.   +11 more
europepmc   +1 more source

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.

Nature Chemical Biology, 2012
Lars Richter, C. de Graaf, W. Sieghart, Zdravko Varagić, M. Mörzinger, I. D. de Esch, G. Ecker, M. Ernst   +7 more
semanticscholar   +1 more source