Results 281 to 290 of about 2,892,311 (358)

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca²⁺ dependent allosteric binding site. [PDF]

Nat Commun
Dakin LA, Xing L, Hall J, Ding W, Vajdos FF, Pelker JW, Ramsey S, Balbo P, Sahasrabudhe PV, Banker ME, Choi WY, Wright SW, Chang JS, Curto JM, Davoren JE, Drozda SE, Fennell KF, Futatsugi K, Kortum S, Lee KL, Liu S, Lovering F, Nicki JA, Trujillo JI, Vincent F, Schnute ME.   +25 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Revealing the genetic diversity and population structure in lentil (Lens culinaris) germplasm using inter-primer binding site (iPBS)-retrotransposon markers. [PDF]

BMC Plant Biol
Qureshi SA, Sarıkaya MF, Nadeem MA, Ali A, Mortazavi P, Bedir M, Tatar M, Madenova A, Kabylbekova B, Ali F, Altaf MT, Soltanbekov S, Tokibayev S, Ilyas MK, Kökten K, Baloch FS.   +15 more
europepmc   +1 more source

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization

Advanced Biology, EarlyView.
This study explores the use of collagen‐hyaluronic acid (HA) hydrogels for the 3D culture of macrophages, providing a useful tool for modelling macrophage behavior in tissues and diseases. It highlights how hydrogel composition, mechanical properties, and preparation methods influence macrophage behavior, revealing for the first time that HA's ...
Tiah CL Oates, Jasmin Boyd, Louise Dolan, C de Kergariou, Jingwen Zhu, Ash Toye, Adam W Perriman, Asme Boussahel   +7 more
wiley   +1 more source

Structure and mechanism of a mycobacterial isoniazid efflux pump MsRv1273c/72c with a degenerate nucleotide-binding site. [PDF]

Nat Commun
Yu J, Lan Y, Zhu C, Chen Z, Pan J, Shi Y, Yang L, Hu T, Gao Y, Zhao Y, Chen X, Yang X, Lu S, Guddat LW, Yang H, Rao Z, Li J.   +16 more
europepmc   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis. [PDF]

Front Immunol
Murao T, Ma G, Murao A, Jha A, Li J, Lee Y, Zhou M, Wang P, Aziz M.   +8 more
europepmc   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

miRBench: novel benchmark datasets for microRNA binding site prediction that mitigate against prevalent microRNA frequency class bias. [PDF]

Bioinformatics
Sammut S, Gresova K, Tzimotoudis D, Marsalkova E, Cechak D, Alexiou P.   +5 more
europepmc   +1 more source