Results 291 to 300 of about 2,892,311 (358)

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL. [PDF]

J Lipid Res
Coleman B, Bedi S, Hill JH, Morris J, Manthei KA, Hart RC, He Y, Shah AS, Jerome WG, Vaisar T, Bornfeldt KE, Song H, Segrest JP, Heinecke JW, Aller SG, Tesmer JJG, Davidson WS.   +16 more
europepmc   +1 more source

Identification of a binding site for small molecule inhibitors targeting human TRPM4. [PDF]

Nat Commun
Ekundayo B, Arullampalam P, Gerber CE, Hämmerli AF, Guichard S, Boukenna M, Ross-Kaschitza D, Lochner M, Rougier JS, Stahlberg H, Abriel H, Ni D.   +11 more
europepmc   +1 more source

KLF14 and SREBF-1 Binding Site Associations with Orphan Receptor Promoters in Metabolic Syndrome. [PDF]

Int J Mol Sci
Garcia-Coste JJ, Villafaña-Rauda S, Aguayo-Cerón KA, Vargas-De-León C, Romero-Nava R.   +4 more
europepmc   +1 more source

Structural insights into binding-site access and ligand recognition by human ABCB1. [PDF]

EMBO J
Kurre D, Dang PX, Le LTM, Gadkari VV, Alam A.   +4 more
europepmc   +1 more source

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D₂ Receptor. [PDF]

ACS Chem Neurosci
Lim HD, Bartuzi D, Keen AC, Rauffenbart C, Glenn J, Charlton SJ, Lovera S, Sands ZA, Ates A, Wood M, Canals M, Javitch JA, Carlsson J, Lane JR.   +13 more
europepmc   +1 more source

A binding site for the antibiotic GE81112 in the ribosomal mRNA channel

Schedlbauer A, Han X, van Bakel W, Kaminishi T, Ochoa-Lizarralde B, Iturrioz I, Çapuni R, Parry R, Zegarra R, Gil-Carton D, López-Alonso JP, Sanz KB, Brandi L, Gualerzi CO, Fucini P, Connell SR.   +15 more
europepmc   +1 more source

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Localization of the binding site on fibrin for the secondary binding site of thrombin

Biochemistry, 1988
Affinity chromatography of active site inhibited thrombin on immobilized fragments derived from the central (desAB-NDSK) and terminal (D1) globular domains of fibrinogen revealed that the site responsible for the binding of thrombin at its secondary fibrin binding site is located in the central domain.
Zsofia Vali, Harold A. Scheraga
openaire   +3 more sources