Results 201 to 210 of about 1,682,340 (366)

Targeting PTPN22 at Nonorthosteric Binding SitesA Fragment Approach. [PDF]

ACS Omega
Di Lello P, Wells MM, Davis B, Daniels Z, Garner TP, Gazzard L, Harris R, Hubbard RE, Landry ML, Martin B, Morgan JLW, Patapoff A, Simmonite H, Skelton N, Ultsch M, Walters BT, Wu P, Dimitrova YN, Huard K.   +18 more
europepmc   +1 more source

Binding energies of the GCMS identified compounds from dichloromethane fraction docked in the active sites of Candida albicans Sterol 14-alpha demethylase (5TZ1) and Escherichia coli DNA gyrase subunit B (6YD9).

Oluwatoyin Temilolu Adebayo (21030152), Bolaji Bosede Oluremi (21030155), Akingbolabo Daniel Ogunlakin (14020076), Gideon Ampoma Gyebi (4514320), Mubo Adeola Sonibare (17673927)   +4 more
openalex   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

AF2BIND: predicting small-molecule binding sites using the pair representation of AlphaFold2. [PDF]

Nat Methods
Gazizov A, Lian A, Goverde C, Mou J, Ovchinnikov S, Polizzi NF.   +5 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Atomically Precise Engineering of Synergistic Binding Sites in a Zirconium Metal-Organic Framework for the Capture of Perfluorooctanoic Acid. [PDF]

J Am Chem Soc
Marugán-Benito S, Vlachos M, Ahrens L, Roselló-González M, Marini C, Prat Albert J, Mavrandonakis A, Loukopoulos E, Platero-Prats AE.   +8 more
europepmc   +1 more source

Localization of Divalent Cation-Binding Site in the Pore of a Small Conductance Ca2+-Activated K+ Channel and Its Role in Determining Current-Voltage Relationship [PDF]

, 2002
Heun Soh, Chul‐Seung Park
openalex   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Unraveling Synthetase's Mode of Action: The Pyrrolysyl-tRNA Synthetase Dimer Uses Secondary Binding Sites in the Cell. [PDF]

Angew Chem Int Ed Engl
Dröden J, Globisch C, Landwehr E, Braun TS, Summerer D, Peter C, Drescher M.   +6 more
europepmc   +1 more source

A hybrid model for robust detection of transcription factor binding sites [PDF]

, 2008
Sumedha Gunewardena, Zhaolei Zhang
openalex   +1 more source