Results 161 to 170 of about 28,047 (270)

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

open access: yesAddiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden   +10 more
wiley   +1 more source

Estimating thresholds for risk of cannabis use disorder using standard delta‐9‐tetrahydrocannabinol (THC) units

open access: yesAddiction, EarlyView.
Abstract Background and aims Lower risk guidelines for safer levels of cannabis use could help to reduce the health burden posed by cannabis use disorder (CUD). We aimed to estimate risk thresholds for CUD based on delta‐9‐tetrahydrocannabinol (THC) consumption using standard THC units (1 unit = 5 mg THC).
Rachel Lees Thorne   +9 more
wiley   +1 more source

Trajectories of genetic risk across dimensions of alcohol use behaviors

open access: yesAddiction, EarlyView.
Abstract Background and aims Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is usually not considered in research identifying and investigating the genes linked to AUBs ...
Jeanne E. Savage   +127 more
wiley   +1 more source

Understanding the Phenomenon of Binge-Watching-A Systematic Review. [PDF]

open access: yesInt J Environ Res Public Health, 2020
Starosta JA, Izydorczyk B.
europepmc   +1 more source

A meta‐analysis of sexual orientation inequities in substance use among youth

open access: yesAddiction, EarlyView.
Abstract Background and Aims Sexual minority youth report significantly higher rates of substance use than heterosexual youth, yet a comprehensive and systematic evaluation and synthesis of the magnitude of this inequity has not been conducted. The purpose of this study was to conduct a meta‐analysis to assess the magnitude of overall inequities in ...
Ethan H. Mereish   +4 more
wiley   +1 more source

Can norm‐based information campaigns reduce corruption?

open access: yesAmerican Journal of Political Science, EarlyView.
Abstract Can norm‐based information campaigns reduce corruption? Such campaigns use messaging about how people typically behave (descriptive norms) or ought to behave (injunctive norms). Drawing on survey and lab experiments in Ukraine, we unpack and evaluate the distinct effects of these two types of social norms.
Aaron Erlich, Jordan Gans‐Morse
wiley   +1 more source

Impact of Evolving Evidence on Pharmacological Therapy for Alcohol‐Associated Hepatitis in Alberta: A Population‐Based Study of Practice Trends and MELD‐Stratified Effectiveness of Corticosteroids

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In this population‐based study in Alberta, Canada, evidence from RCTs led to a rapid reversal in pentoxifylline use, prior to formal guideline updates. Real‐world data support a modest short‐term benefit of CS and illustrate the potential of target trial emulation to assess treatment effectiveness in specific groups of patients. ABSTRACT Background and
Abdel‐Aziz Shaheen   +3 more
wiley   +1 more source

Let's Co! The how‐to of working within a co‐production framework to devise, design and execute collaborative multisite clinical trials

open access: yesBritish Journal of Clinical Psychology, EarlyView.
Abstract Objectives To document the steps undertaken in a full collaborative co‐production design process undertaken between a group of lived experience, clinical and research collaborators to determine the selection and design of three large‐scale, multisite, clinically focused studies (including two clinical trials) targeting eating disorders.
Sarah Maguire   +23 more
wiley   +1 more source

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