Results 131 to 140 of about 180,663 (331)

On sums of binomial coefficients [PDF]

open access: yesProyecciones (Antofagasta)
We investigate the integral representation of infinite sums involving the ratio of binomial coefficients. We also recover some wellknown properties of ζ (3) and extend the range of results given by other authors. 
openaire   +2 more sources

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker   +20 more
wiley   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin   +6 more
wiley   +1 more source

Neurofeedback for Binge‐Eating Disorder: Neurophysiological Outcome Predictors and Rapid Response

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Pioneer studies suggested the effectiveness of food‐specific electroencephalography (EEG) and real‐time functional near‐infrared spectroscopy (rtfNIRS) neurofeedback (NF) trainings in the treatment of binge‐eating disorder (BED). These trainings aim to improve participants' neurophysiological self‐regulation.
Ben Schreglmann   +3 more
wiley   +1 more source

Species distribution modeling with expert elicitation and Bayesian calibration

open access: yesEcography, EarlyView.
Species distribution models (SDM) are key tools in ecology, conservation, and natural resources management. They are traditionally trained with data on direct species observations. However, if collecting species data is difficult or expensive, complementary information sources on species distributions are needed.
Karel Kaurila   +3 more
wiley   +1 more source

Demography and dispersal influence the relationship between habitat suitability and population density

open access: yesEcography, EarlyView.
A central goal of ecology is to understand spatial patterns of species densities. Habitat suitability estimates from species distribution models (SDMs) could be used to represent species density and overcome the scarcity of density data. However, there is mixed evidence that habitat suitability is a reliable descriptor of density, and it is suggested ...
Cleber Ten Caten, Tad Dallas
wiley   +1 more source

Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.
Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta   +5 more
wiley   +1 more source

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