Results 91 to 100 of about 23,921,395 (244)

Preparation of and research on bioinspired graphene oxide/nanocellulose/polydopamine ternary artificial nacre

Materials & Design, 2019
Inspired by the hierarchical micro/nanoscale structure and interfacial interactions of natural nacre, a variety of bioinspired layered materials were designed and prepared.
Muzhi Li, Yuanyuan Miao, Xueyong Zhai, Yuxue Yin, Yuanting Zhang, Zhibin Jian, Xiuya Wang, Lipeng Sun, Zhenbo Liu   +8 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 109 (1992-04)

, 1992
Bio-Medical Library. (1992). Bio-Medical Library Bulletin, No. 109 (1992-04).
Bio-Medical Library
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 23 (1971-11)

, 1971
Bio-Medical Library. (1971). Bio-Medical Library Bulletin, No. 23 (1971-11).
Bio-Medical Library
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 89 (1986-02)

, 1986
Bio-Medical Library. (1986). Bio-Medical Library Bulletin, No. 89 (1986-02).
Bio-Medical Library
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 07 (1969-05)

, 1969
Bio-Medical Library. (1969). Bio-Medical Library Bulletin, No. 07 (1969-05).
Bio-Medical Library
core  

Engineering transverse cell deformation of bamboo by controlling localized moisture content

Nature Communications
Bamboo’s native structure, defined by the vertical growth pattern of its vascular bundles and parenchyma cell tissue, limits its application in advanced engineering materials.
Tian Bai, Jie Yan, Jiqing Lu, Jie Zhou, Hang Yao, Xiuwen He, Shaohua Gu, Zhihan Tong, Sheldon Q. Shi, Jian Li, Wanli Cheng, Dong Wang, Guangping Han, Chaoji Chen   +13 more
doaj   +1 more source