Results 101 to 110 of about 23,921,395 (244)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 78 (1983-04)

, 1983
Bio-Medical Library. (1983). Bio-Medical Library Bulletin, No. 78 (1983-04).
Bio-Medical Library
core  

Renewable Methacrylate Resins for 3D Printing Containing Dynamic Hydroxyester Linkages for Reprocessability

Macromolecular Materials and Engineering
To facilitate the ongoing transition toward a circular economy, renewable 3D print materials that are both sustainable and competitive must be accessible.
Kylian Janssen, Geraldine H.M. Schnelting, Mirte Waterink, Jarno Guit, Jerzy Hul, Chongnan Ye, Katja Loos, Vincent S.D. Voet   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 51 (1977-04)

, 1977
Bio-Medical Library. (1977). Bio-Medical Library Bulletin, No. 51 (1977-04).
Bio-Medical Library
core  

Tamper-Proof Time–Temperature Indicator for Inspecting Ultracold Supply Chain

ACS Omega, 2021
Lam Tan Hao, Minkyung Lee, Hyeonyeol Jeon, Jun Mo Koo, Sung Yeon Hwang, Dongyeop X. Oh, Jeyoung Park   +6 more
doaj   +1 more source

Typical Applications and Flame‐Retardant Strategies for Organic Phase‐Change Materials

Carbon Energy
This study begins by exploring the typical practical applications of phase‐change materials (PCMs) in various industries, highlighting their importance in energy storage, temperature regulation, and thermal management. It then emphasizes the necessity of
Xiao‐Mei Yang, Tao Shi, Xiaodong Wang, Huan Liu, De‐Yi Wang, Guang‐Zhong Yin   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source