Results 61 to 70 of about 28,595,985 (299)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Preparation of Partridge Tea Extract-Artemisia sphaerocephala Krasch Gum Composite Film and Its Application in Preservation of Cooked Chicken

Shipin gongye ke-ji
Partridge tea extract (PTE) extracted by hot-water was blended with Artemisia sphaerocephala Krasch gum (ASKG) to prepare ASKG-PTE composite films for packaging cooked chicken and extending the shelf life.
Na WEI, Zijing PAN, Wenhua LIU, Yuping NING, Xin WEN, Chen YANG, Lijuan WANG   +6 more
doaj   +1 more source

LIGNIN BIO-BASED MATERIAL IN UNSATURATED POLYESTER

Cellulose Chemistry and Technology, 2019
The potential utilization of lignin, as a natural-based material, in unsaturated polyester (UPE) has been investigated. Kraft (Indulin AT) and sulfite lignin (ArboSO1) samples from forestry biomass and their consistencies in UPE were evaluated by qualitative and quantitative methods.
Ngo, Tri-Dung, Patenaude, Eric, Ahvazi, Behzad   +2 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Aligned core-sheath structured fibers prevent intimal hyperplasia via modulate macrophage polarization and smooth muscle cell phenotype in vascular regeneration

Journal of Nanobiotechnology
Small-diameter vascular grafts face limited success due to thrombosis, intimal hyperplasia, and insufficient remodeling. Here, we developed a tubular graft composed of aligned core-sheath structured PLCL fibers with sodium tanshinone IIA sulfonate (STS ...
Yunhuan Li, Yutong Liu, Kuihua Zhang, Nan Jiang, Keqing Hou, Liyu Chen, Fan Lin, Zhiyong Yan, Changlin Zhai, Tonghe Zhu, Anlin Yin   +10 more
doaj   +1 more source

Synergistic Engineering of the Twin-Arginine Translocation (Tat) Pathway and Membrane Capacity Enhances Extracellular Production of Amylosucrase in Bacillus licheniformis

Microorganisms
Amylosucrase (AS) is a highly versatile enzyme with significant potential for industrial applications, including functional food production and glycosylation of bioactive compounds.
Caizhe Wang, Dandan Niu, Yongqing Zhou, Hui Liu, Nokuthula Peace Mchunu, Meng Zhang, Suren Singh, Zhengxiang Wang   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Metabolomics-Based Elucidation of the Lipid-Lowering Mechanisms of Monascus Vinegar Polysaccharides

Foods
Monascus vinegar (MV) is a functional food containing various bioactive components, which has attracted significant research attention due to the unique health benefits conferred by these active functional ingredients. This study aimed to investigate the
Yanhua Liu, Yueyue Wu, Shuo Wang, Senzhen Lin, Bingning Gao, Chenyu Yang, Jia Song, Min Wang   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Hygrothermal Properties and Performance of Bio-Based Insulation Materials Locally Sourced in Sweden

In recent years, there has been a paradigm shift in the building sector towards more sustainable, resource efficient, and renewable materials. Bio-based insulation derived from renewable resources, such as plant or animal fibres, is one promising group ...
Wadsö, Lars,, Strandberg, Paulien,, Lund University., Ranefjärd, Oskar,, Ranefjärd, Oskar, Oskar Ranefjärd, Lars Wadsö, Strandberg-de Bruijn, Paulien B., Strandberg, Paulien, Wadsö, Lars, Paulien B. Strandberg-de Bruijn   +10 more
core   +2 more sources