Results 51 to 60 of about 28,595,985 (299)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Magnesia-silicate based binders for hempcrete

, 2023
Composite building materials composed of bio-based aggregates and cementitious binders gained more and more interest in the last decades due to their low embodied CO2.
Douillet, Guilhem Amin (author), Zucha, Wolfgang Jan (author), Bernard, Ellina (author), Toropovs, Nikolajs (author)   +3 more
core   +1 more source

Performance of buildings

, 2017
The chapter deals with different aspects on the use and performance of bio-based building materials in constructions and buildings.
Bardage, Stig,, S.L. Bardage
core   +1 more source

Bio-based polymeric materials from vegetable oils [PDF]

, 2014
Vegetable oils have been utilized in developing various types of bio-based materials in my research work. Bio-based polyhydroxy fatty acids have been subject to ring-opening epoxidized soybean oil with alkaline catalyst DBU to generate polyols with ...
Chen, Ruqi
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Decoupling sucrose utilization from oxygen-responsive regulation for high-efficiency L-lactic acid production in Escherichia coli

Biotechnology for Biofuels and Bioproducts
The shift toward sustainable biomanufacturing necessitates microbial platforms that efficiently convert low-cost, non-food feedstocks into high-value chemicals. Sucrose, a widely available and economical carbon source, remains underutilized in industrial 
Meng Wang, Dandan Niu, Mingliang Gao, Anqi Wang, Wenbin Zhao, Kugen Permaul, Suren Singh, Zhengxiang Wang   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Polydopamine Induced Wettability Switching of Cellulose Nanofibers/n-Dodecanethiol Composite Aerogels

International Journal of Polymer Science, 2022
The novel wettability switchable cellulose nanofiber- (CNF-) based aerogel was conveniently prepared by polydopamine mediated composition of CNF and n-dodecanethiol.
Runan Gao, Ying Shang, Peng Jiao, Yue Jiao, Jian Li, Yun Lu   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Synergistic reinforcement of PVA films with boric acid and nano-silica for high-barrier food packaging

Polymer Testing
The increasing environmental crisis caused by the extensive use of disposable plastics highlights the pressing demand for sustainable options. This research investigates an innovative method for enhancing the traits of polyvinyl alcohol (PVA) through the
Xinyu Xu, Siqi Xie, Baoying Shi, Di Wu, Yu Lin, Qiaohui Zhi, Yufeng Wang, Haiyan Song   +7 more
doaj   +1 more source