Results 81 to 90 of about 244,930 (304)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Bio-Based Solvents for Organic Synthesis [PDF]

, 2013
Scrutiny over solvent selection in the chemical industry has risen in recent decades, popularising research into neoteric solvent systems such as ionic liquids and supercritical fluids.
Sherwood, James
core  

Solvent-Free One-Shot Synthesis of Thermoplastic Polyurethane Based on Bio-Poly(1,3-propylene succinate) Glycol with Temperature-Sensitive Shape Memory Behavior

, 2020
In this work, a new family of fully biobased thermoplastic polyurethanes (TPUs) with thermo-induced shape memory is developed. First, a series of TPUs were successfully synthesized by the one-shot solvent-free bulk polymerization of bio-poly­(1,3 ...
Syang-Peng Rwei (1926217), Po-Han Chen, Fu-Sheng Chuan (8473656), Palraj Ranganathan, Chien-Hui Wu (8473653), Cattaleeya Pattamaprom, Syang-Peng Rwei, Palraj Ranganathan (6666869), Fu-Sheng Chuan, Yu-Lin Huang (129544), Cattaleeya Pattamaprom (8473650), Po-Han Chen (207950), Yu-Lin Huang, Chien-Hui Wu   +13 more
core   +1 more source

Solvent-free synthesis of bio-based N-isobutyl-5-methyloxazolidinone: an eco-friendly solvent

RSC Advances
Large-scale synthesis of bio-based oxazolidinone as an eco-friendly solvent from biomass using a bio-based organocatalyst.
Fournier, Antoine, Suisse, Jean-Moïse, de Frémont, Pierre, Andrieu, Jacques   +3 more
openaire   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A solvent-free, base-catalyzed domino reaction towards trifluoromethylated benzenes from bio-based methyl coumalate

, 2018
An efficient and sustainable method to prepare pharmaceutically important trifluoromethyl-benzenes from bio-based methyl coumalate in high yields, in a solvent-free tBuOK-catalyzed domino sequence.
Luc Dechoux, Liang Chang, Nadja Klipfel, Serge Thorimbert   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Experimental approach versus COSMO-RS assisted solvent screening for predicting the solubility of rapeseed oil

Oilseeds and fats, crops and lipids, 2015
Vegetable oils take a large part in industry for food and non-food applications. However the extraction process of oil from oilseeds includes a solvent extraction step using hexane.
Sicaire Anne-Gaëlle, Abert Vian Maryline, Fine Frédéric, Carré Patrick, Tostain Sylvain, Chemat Farid   +5 more
doaj   +1 more source

Eco‐Friendly Bio‐Based Solvents for the Acetylation of the Amino Group of Amino Acids

Chemistry & Biodiversity
AbstractNature‐derived products, like juices and peel extracts of fruits and vegetables, have emerged in recent years as interesting and sustainable alternatives to traditional solvents in several synthetic applications. Herein, we present a green and fast method for the N‐acetylation of amino acids, using several bio‐based solvents (vinegar, tomato ...
Cazzaniga G., Tresoldi A., Gelain A., Meneghetti F., Mori M., Villa S.   +5 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source