Results 41 to 50 of about 4,761 (245)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Homing Ability of Adélie Penguins Investigated with Displacement Experiments and Bio-Logging [PDF]
Ardea, 2020 Adelie Penguins Pygoscelis adeliae live exclusively in Antarctica and commute between the sea for foraging and the land for breeding. During these movements, they must navigate various environments: underwater, on sea ice and on land; an unusual set of challenges among animals.
Kozue Shiomi +3 more
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tracking the Conservation Promise of Movement Ecology
Frontiers in Ecology and Evolution, 2018 From butterflies to elephants, the rapidly developing science of movement ecology is providing increasingly detailed spatio-temporal data on a wide array of mobile animals.
Kevin C. Fraser +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Optimal deep learning activity recognition pipeline using animal bio‐logging data
Methods in Ecology and EvolutionAnimal activity recognition using supervised machine learning on bio‐logging data has revolutionized behavioural studies on wildlife and livestock over the past decade. These studies' analytic pipelines differ substantially though, being based on various
Jasper A. J. Eikelboom
doaj +1 more source
Effect of harness design for tag attachment on the flight performance of five soaring species
Movement Ecology, 2023 Background Bio-logging devices play a fundamental and indispensable role in movement ecology studies, particularly in the wild. However, researchers are aware of the influence that attaching devices can have on animals, particularly on their behaviour ...
Arianna Longarini +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source