Results 51 to 60 of about 4,761 (245)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Behavioural networks: a new methodology to study birds’ habits [PDF]

Network Biology, 2019
We introduce here a new methodology, named Behavioural Networks (BeNe), to thoroughly analyze birds’ habits in space and time. Behavioural Networks are based on GIS technologies, association rules and network capabilities, all applied to GPS data.
Alessandro Ferrarini, Giuseppe Giglio, Stefania C. Pellegrino, et al.   +2 more
doaj  

Overall Dynamic Body Acceleration in Straw-Colored Fruit Bats Increases in Headwinds but Not With Airspeed

Frontiers in Ecology and Evolution, 2019
Atmospheric conditions impact how animals use the aerosphere, and birds and bats should modify their flight to minimize energetic expenditure relative to changing wind conditions.
M. Teague O'Mara, M. Teague O'Mara, M. Teague O'Mara, Anne K. Scharf, Anne K. Scharf, Anne K. Scharf, Jakob Fahr, Jakob Fahr, Michael Abedi-Lartey, Michael Abedi-Lartey, Martin Wikelski, Martin Wikelski, Martin Wikelski, Dina K. N. Dechmann, Dina K. N. Dechmann, Dina K. N. Dechmann, Kamran Safi, Kamran Safi, Kamran Safi   +18 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Apparent reduction in heart rate during oviposition revealed by non-invasive heart rate monitoring of gravid loggerhead turtles

Frontiers in Physiology
Reproductive processes place significant physiological demands on animals, often accompanied by hormonal and neural changes. In this study, we examined changes in heart rate of gravid loggerhead turtles (Caretta caretta) during nesting activities on the ...
Tomoko Narazaki, Masanori Mori, Yoshimasa Matsuzawa, Ayaka Saito, Chihiro Kinoshita, Masanori Kurita, Kensuke Matsumiya, Hikari Okada, Kentaro Q. Sakamoto   +8 more
doaj   +1 more source

Tools for integrating inertial sensor data with video bio-loggers, including estimation of animal orientation, motion, and position

Animal Biotelemetry, 2021
Bio-logging devices equipped with inertial measurement units—particularly accelerometers, magnetometers, and pressure sensors—have revolutionized our ability to study animals as necessary electronics have gotten smaller and more affordable over the last ...
David E. Cade, William T. Gough, Max F. Czapanskiy, James A. Fahlbusch, Shirel R. Kahane-Rapport, Jacob M. J. Linsky, Ross C. Nichols, William K. Oestreich, Danuta M. Wisniewska, Ari S. Friedlaender, Jeremy A. Goldbogen   +10 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Stable Isotope Dynamics (δ13C and δ15N) in Neritic and Oceanic Waters of the North Atlantic Inferred From GPS-Tracked Cory’s Shearwaters

Frontiers in Marine Science, 2018
Intrinsic markers, such as stable isotopes, are a powerful approach to trace wildlife movements because they do not require initial marking of the organism.
Filipe R. Ceia, Yves Cherel, Vitor H. Paiva, Jaime A. Ramos   +3 more
doaj   +1 more source