Results 71 to 80 of about 6,578 (291)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Estimating Seasonal Behavior States from Bio-logging Sensor Data

, 2015
The seasonal timing of key, annual life history events is an important component of many species' ecology. Seasonal periods important to marine mammals often do not align well with typical labels (i.e., spring, summer, winter, fall). The timing of key life history events is well documented only for species found in accessible rookeries or breeding ...
London, Josh, Johnson, Devin, Conn, Paul, McClintock, Brett, Cameron, Michael, Boveng, Peter   +5 more
openaire   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Genesis and evolution of bio-logging devices: l963-2002 [PDF]

, 2004
Bio-logging devices have become an integral part of many studies on the behavior, physiology and ecology of marine vertebrates. In the beginning, 1963, a time depth recorder (TDR) was designed to measure time and depth of freely diving Weddell seals ...
Gerald L. Kooyman
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Developmental stage shapes the realized energy landscape for a flight specialist

eLife
The heterogeneity of the physical environment determines the cost of transport for animals, shaping their energy landscape. Animals respond to this energy landscape by adjusting their distribution and movement to maximize gains and reduce costs.
Elham Nourani, Louise Faure, Hester Brønnvik, Martina Scacco, Enrico Bassi, Wolfgang Fiedler, Martin U Grüebler, Julia S Hatzl, David Jenny, Andrea Roverselli, Petra Sumasgutner, Matthias Tschumi, Martin Wikelski, Kamran Safi   +13 more
doaj   +1 more source

Initial application of bio-logging techniques on captive Milky Storks (Mycteria cinerea) in Malaysia. [PDF]

, 2012
The use of remote sensing equipment on animals (i.e. bio-logging) is increasingly being used to understand numerous variables about their life at very fine temporal scales.
Ismail, Ahmad, Miyazaki, N., Naito, Y., Rahman, Faid   +3 more
core  

Development of an animal-borne blood sample collection device and its deployment for the determination of cardiovascular and stress hormones in phocid seals [PDF]

, 2016
The research was supported by Bilateral Program between Japan and the United Kingdom and a Grant-in-Aid for Scientific Research (23247010) to Y. Takei and by Grant-in-Aid for challenging Exploratory Research (15K14567) to I. Suzuki from the Japan Society
Hall, Ailsa, Milne, Ryan, Moss, Simon, Sato, Katsufumi, Suzuki, Ippei, Takei, Yoshio, Wong, Marty K. S.   +6 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Geolocation and immersion loggers reveal year‐round residency and facilitate nutrient deposition rate estimation of adult red‐footed boobies in the Chagos Archipelago, tropical Indian Ocean

Journal of Avian Biology
Bio‐logging has revealed much about high‐latitude seabird migratory strategies, but migratory behaviour in tropical species may differ, with implications for understanding nutrient deposition.
Stephen C. Votier, Grace Corcoran, Pete Carr, Ruth E. Dunn, Robin Freeman, Malcolm A. C. Nicoll, Hannah Wood, Alice M. Trevail   +7 more
doaj   +1 more source